Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 7/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1988924 | 1.00 | PDE2A (0.39) | PDE2ANPSR1HSD17B10MAPTCHRM4 | |
| SCHEMBL12563482 | 0.87 | PDE2A (0.44) | PDE2ANPSR1HSD17B10MAPTCHRM4 | |
| SCHEMBL1989197 | 0.83 | PDE2A (0.40) | PDE2A | |
| SCHEMBL13513932 | 0.83 | PDE2A (0.40) | PDE2A | |
| SCHEMBL12697484 | 0.83 | HDAC1 (0.41) | PDE2AHSD17B10HPGD | |
| SCHEMBL1660660 | 0.83 | HDAC1 (0.41) | PDE2AHSD17B10HPGD | |
| SCHEMBL1987320 | 0.82 | NLRP3 (0.39) | PDE2ANLRP3 | |
| SCHEMBL12604221 | 0.81 | PDE2A (0.39) | PDE2ANPSR1HSD17B10HPGD | |
| SCHEMBL1988758 | 0.81 | PDE2A (0.39) | PDE2AHSD17B10HPGD | |
| SCHEMBL12697446 | 0.81 | PDE4B (0.45) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307394-B1 | SULPHONAMIDES AS VANILLOID RECEPTOR ANTAGONIST | AMOREPACIFIC CORP (KR) | 2012-09-26 | — | — | EP | disclosed |
| WO-2010002209-A2 | NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | AMOREPACIFIC CORPORATION (KR) | 2010-01-07 | — | — | WO | disclosed |