Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAUR | Q03405 | 11/20 | 0.86 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.73 |
| ▸ | PLAU | P00749 | 1/20 | 0.67 |
| ▸ | EHMT2 | Q96KQ7 | 4/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16622147 | 0.85 | NTRK1 (0.90) | PLAURNTRK1PLAUEHMT2GSK3B | |
| SCHEMBL13284987 | 0.84 | NTRK1 (1.00) | PLAURNTRK1PLAUEHMT2GSK3B | |
| SCHEMBL20224677 | 0.83 | PLAUR (0.72) | PLAURNTRK1PLAUEHMT2GSK3B | |
| SCHEMBL18486769 | 0.83 | PLAUR (0.72) | PLAURNTRK1PLAUEHMT2GSK3B | |
| SCHEMBL13284995 | 0.83 | NTRK1 (0.86) | PLAURNTRK1PLAUEHMT2GSK3B | |
| SCHEMBL12698763 | 0.83 | PLAUR (1.00) | PLAURNTRK1PLAUEHMT2GSK3B | |
| SCHEMBL17874501 | 0.82 | PLAUR (0.82) | PLAURNTRK1PLAUEHMT2MAPT | |
| SCHEMBL30019219 | 0.80 | PLAU (1.00) | PLAURNTRK1PLAUEHMT2GSK3B | |
| SCHEMBL12499325 | 0.80 | PLAU (1.00) | PLAURNTRK1PLAUEHMT2GSK3B | |
| SCHEMBL17874500 | 0.80 | PLAU (0.81) | PLAURNTRK1PLAUEHMT2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376406-B2 | uPAR-uPA interaction inhibitors and methods for treating cancer | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2016-06-28 | — | — | US | disclosed |
| US-9376406-B2 | uPAR-uPA interaction inhibitors and methods for treating cancer | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2016-06-28 | — | — | US | disclosed |
| WO-2012119079-A1 | uPAR-uPA INTERACTION INHIBITORS AND METHODS FOR TREATING CANCER | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2012-09-07 | — | — | WO | disclosed |