Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 15/20 | 0.54 |
| ▸ | VNN1 | O95497 | 1/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4475347 | 0.86 | NPC1 (0.60) | NPC1RAB9AVNN1CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL3539826 | 0.84 | NPC1 (0.58) | NPC1RAB9AVNN1CYP11B1CYP11B2 | |
| SCHEMBL3537983 | 0.83 | NPC1 (0.59) | NPC1RAB9AABL1VNN1CYP11B1 | |
| SCHEMBL30706505 | 0.83 | CYP11B1 (0.62) | NPC1RAB9AABL1CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL3541282 | 0.81 | NPC1 (0.57) | NPC1RAB9AABL1VNN1CYP11B1 | |
| SCHEMBL17157370 | 0.80 | ABL1 (0.49) | NPC1RAB9AABL1 | |
| SCHEMBL17157486 | 0.80 | ABL1 (0.49) | NPC1RAB9AABL1 | |
| SCHEMBL9288749 | 0.80 | ABL1 (0.51) | NPC1RAB9AABL1KCNH2 | |
| SCHEMBL4602009 | 0.79 | ELANE (0.56) | NPC1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL22721360 | 0.79 | EPHX2 (0.62) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169216-B2 | Method for preparation of 5-substituted pyrimidines | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2015-10-27 | — | — | US | disclosed |
| US-9169216-B2 | Method for preparation of 5-substituted pyrimidines | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2015-10-27 | — | — | US | disclosed |
| US-20140121375-A1 | METHOD FOR PREPARATION OF 5-SUBSTITUTED PYRIMIDINES | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2014-05-01 | — | — | US | disclosed |
| US-20140121375-A1 | METHOD FOR PREPARATION OF 5-SUBSTITUTED PYRIMIDINES | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2014-05-01 | — | — | US | disclosed |
| WO-2012128965-A2 | METHOD FOR PREPARATION OF 5-SUBSTITUTED PYRIMIDINES | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2012-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140121375-A1 | METHOD FOR PREPARATION OF 5-SUBSTITUTED PYRIMIDINES | DPYD, TYMP, DUT | NPC1 4518/4885RAB9A 3495/4885ABL1 748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.