Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | HRH1 | P35367 | 1/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12422565 | 0.96 | PLK1 (0.63) | PLK1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL3980469 | 0.90 | PLK1 (0.61) | PLK1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL3981507 | 0.90 | PLK1 (0.61) | PLK1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL3981757 | 0.90 | PLK1 (0.61) | PLK1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL3976758 | 0.90 | PLK1 (0.61) | PLK1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL13382890 | 0.89 | PLK1 (0.63) | PLK1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL24219845 | 0.87 | PLK1 (0.64) | PLK1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL1041880 | 0.87 | HTR1A (0.62) | PLK1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL1041626 | 0.87 | HTR1A (0.62) | PLK1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL3979860 | 0.84 | HTR1A (0.62) | PLK1HTR1AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919581-B2 | Bi-dentate compounds as kinase inhibitors | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-04-05 | — | — | US | disclosed |
| US-7919581-B2 | Bi-dentate compounds as kinase inhibitors | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-04-05 | — | — | US | disclosed |
| US-20090054348-A1 | BI-DENTATE COMPOUNDS AS KINASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-02-26 | — | — | US | disclosed |
| US-20090054348-A1 | BI-DENTATE COMPOUNDS AS KINASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054348-A1 | BI-DENTATE COMPOUNDS AS KINASE INHIBITORS | MAP2K2, MAP2K1, MAP2K7 | PLK1 182/4885HTR1A 2063/4885ADRA2A 1777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.