Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 14/20 | 0.45 |
| ▸ | INSR | P06213 | 9/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20567095 | 0.86 | ALK (0.39) | ALKINSRKCNH2TRPC6 | |
| SCHEMBL12705526 | 0.86 | ALK (0.47) | ALKINSRKCNH2TRPC6 | |
| SCHEMBL1014832 | 0.85 | ALK (0.48) | ALKINSRKCNH2TRPC6 | |
| SCHEMBL1014752 | 0.85 | ALK (0.43) | ALKINSRKCNH2TRPC6 | |
| SCHEMBL13724181 | 0.85 | DRD2 (0.44) | ALKINSRGAARAD52 | |
| SCHEMBL19372818 | 0.85 | CCR5 (0.43) | ALKINSR | |
| SCHEMBL24950411 | 0.84 | ALK (0.47) | ALKINSRKCNH2TRPC6 | |
| SCHEMBL12705456 | 0.84 | ALK (0.42) | ALKINSRKCNH2TRPC6 | |
| SCHEMBL13654843 | 0.84 | ALK (0.45) | ALKINSRKCNH2 | |
| SCHEMBL19358319 | 0.83 | MEN1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2537830-A1 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2012-12-26 | — | — | EP | disclosed |
| EP-2311807-A1 | Compounds and composition as protein kinase inhibitors | IRM LLC (BM) | 2011-04-20 | — | — | EP | disclosed |
| WO-2008073687-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-06-19 | — | — | WO | disclosed |