Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | CNR2 | P34972 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13068963 | 0.87 | ACKR3 (0.56) | ACKR3TP53CNR2POLBSMN1; SMN2 | |
| SCHEMBL12707248 | 0.85 | ACKR3 (0.79) | ACKR3TP53CNR2POLBSMN1; SMN2 | |
| SCHEMBL14535577 | 0.84 | ACKR3 (0.59) | ACKR3TP53CNR2POLBSMN1; SMN2 | |
| SCHEMBL12707290 | 0.83 | ACKR3 (0.55) | ACKR3TP53CNR2POLBSMN1; SMN2 | |
| SCHEMBL13069581 | 0.82 | ACKR3 (0.55) | ACKR3TP53CNR2POLBSMN1; SMN2 | |
| SCHEMBL14535523 | 0.81 | MAPT (0.58) | ACKR3TP53CNR2POLBSMN1; SMN2 | |
| SCHEMBL14535521 | 0.81 | ACKR3 (0.57) | ACKR3TP53CNR2POLBSMN1; SMN2 | |
| SCHEMBL14535532 | 0.81 | SMN1; SMN2 (0.59) | ACKR3TP53CNR2POLBSMN1; SMN2 | |
| SCHEMBL13069441 | 0.81 | ACKR3 (0.55) | ACKR3TP53CNR2POLBSMN1; SMN2 | |
| SCHEMBL13068971 | 0.81 | ACKR3 (0.57) | ACKR3TP53CNR2POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2314590-A1 | Substituted quinolones and methods of use | ChemoCentryx, Inc. (US) | 2011-04-27 | — | — | EP | disclosed |