Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.45 |
| ▸ | MEN1 | O00255 | 10/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.45 |
| ▸ | TP53 | P04637 | 9/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.43 |
| ▸ | HPGD | P15428 | 8/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13388312 | 1.00 | MAPT (0.45) | MAPTMEN1KMT2ATP53MAPK1 | |
| SCHEMBL13388073 | 0.84 | PFKFB3 (0.43) | MAPTMAPK1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL13388076 | 0.84 | PFKFB3 (0.43) | MAPTMAPK1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL13387797 | 0.82 | MAPT (0.47) | MAPTMEN1KMT2ATP53MAPK1 | |
| SCHEMBL12710006 | 0.82 | MAPT (0.47) | MAPTMEN1KMT2ATP53MAPK1 | |
| SCHEMBL13551646 | 0.82 | MEN1 (0.53) | MAPTMEN1KMT2ATP53MAPK1 | |
| SCHEMBL13388526 | 0.81 | CYP1A1 (0.41) | HSD17B10 | |
| SCHEMBL13388482 | 0.81 | MAOB (0.48) | MAPTKMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL12709989 | 0.81 | RAB9A (0.41) | MAPTMEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL12709789 | 0.81 | CYP1A1 (0.41) | HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8916711-B2 | Imidazothiazole-chalcone derivatives as potential anticancer agents and process for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2014-12-23 | — | — | US | claimed |
| US-20120271054-A1 | IMIDAZOTHIAZOLE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2012-10-25 | — | — | US | claimed |
| US-8916711-B2 | Imidazothiazole-chalcone derivatives as potential anticancer agents and process for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2014-12-23 | — | — | US | disclosed |
| US-8916711-B2 | Imidazothiazole-chalcone derivatives as potential anticancer agents and process for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2014-12-23 | — | — | US | disclosed |
| EP-2488533-B1 | IMIDAZOTHIAZOLE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2014-07-23 | — | — | EP | disclosed |
| EP-2488533-B1 | IMIDAZOTHIAZOLE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2014-07-23 | — | — | EP | disclosed |
| US-20120271054-A1 | IMIDAZOTHIAZOLE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2012-10-25 | — | — | US | disclosed |
| US-20120271054-A1 | IMIDAZOTHIAZOLE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2012-10-25 | — | — | US | disclosed |
| WO-2011045646-A1 | IMIDAZOTHIAZOLE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120271054-A1 | IMIDAZOTHIAZOLE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | EIF4A1, CYP2C18, UGT2B17 | MAPT 3057/4885MEN1 2545/4885KMT2A 1313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.