Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 16/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | CD38 | P28907 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13093092 | 0.93 | BDKRB2 (0.61) | BDKRB2CYP3A4CYP2C19ADORA2ACD38 | |
| SCHEMBL12712312 | 0.87 | BDKRB2 (0.53) | BDKRB2CYP3A4CYP2C19 | |
| SCHEMBL12712405 | 0.86 | BDKRB2 (0.62) | BDKRB2CYP3A4CYP2C19ADORA2A | |
| SCHEMBL12711402 | 0.84 | BDKRB2 (0.69) | BDKRB2CYP3A4CYP2C19ADORA2ACD38 | |
| SCHEMBL12711916 | 0.83 | BDKRB2 (0.62) | BDKRB2CYP3A4CYP2C19ADORA2A | |
| SCHEMBL12711415 | 0.82 | BDKRB2 (0.47) | BDKRB2CYP3A4 | |
| SCHEMBL12712279 | 0.81 | BDKRB2 (0.67) | BDKRB2CYP3A4CYP2C19ADORA2ACD38 | |
| SCHEMBL12711423 | 0.81 | BDKRB2 (0.60) | BDKRB2CYP3A4CYP2C19ADORA2A | |
| SCHEMBL12711417 | 0.80 | BDKRB2 (0.45) | BDKRB2CYP3A4CYP2C19 | |
| SCHEMBL12711912 | 0.79 | BDKRB2 (0.59) | BDKRB2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305668-A1 | 8-oxy-quinoline derivatives as bradykinin B2 receptor modulators | Jerini AG (DE) | 2011-04-06 | — | — | EP | disclosed |
| EP-2144897-B1 | 8-OXY-QUINOLINE DERIVATIVES AS BRADYKININ B2 RECEPTOR MODULATORS | JERINI AG (DE) | 2010-10-20 | — | — | EP | disclosed |