Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 6/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | BLM | P54132 | 4/20 | 0.33 |
| ▸ | RGS12 | O14924 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12715623 | 1.00 | GABRA1 (0.45) | GABRA1GABRG2GABRB3EGFRERBB2 | |
| SCHEMBL13681481 | 0.85 | EGFR (0.52) | EGFRERBB2ALDH1A1CYP3A4TDP1 | |
| SCHEMBL13681565 | 0.84 | EGFR (0.46) | GABRA1GABRG2GABRB3EGFRERBB2 | |
| SCHEMBL17884073 | 0.81 | EGFR (0.43) | GABRA1GABRG2GABRB3EGFRERBB2 | |
| SCHEMBL17873660 | 0.81 | EGFR (0.43) | GABRA1GABRG2GABRB3EGFRERBB2 | |
| SCHEMBL17873661 | 0.81 | EGFR (0.43) | GABRA1GABRG2GABRB3EGFRERBB2 | |
| SCHEMBL13681521 | 0.78 | EGFR (0.41) | GABRA1GABRG2GABRB3EGFRERBB2 | |
| SCHEMBL21056104 | 0.78 | GABRA1 (0.49) | GABRA1GABRG2GABRB3EGFRERBB2 | |
| SCHEMBL21056103 | 0.78 | GABRA1 (0.49) | GABRA1GABRG2GABRB3EGFRERBB2 | |
| SCHEMBL21134491 | 0.78 | GABRA1 (0.49) | GABRA1GABRG2GABRB3EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797050-B1 | HIV INHIBITING 1.2.4-TRIAZIN-6-ONE DERIVATES | JANSSEN PHARMACEUTICA NV (BE) | 2013-10-23 | — | — | EP | disclosed |
| US-7923554-B2 | HIV inhibiting 1,2,4-triazin-6-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-04-12 | — | — | US | disclosed |
| US-7923554-B2 | HIV inhibiting 1,2,4-triazin-6-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-04-12 | — | — | US | disclosed |
| US-20090012092-A1 | Hiv Inhibiting 1,2,4-Triazin-6-One Derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-08 | — | — | US | disclosed |
| US-20090012092-A1 | Hiv Inhibiting 1,2,4-Triazin-6-One Derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-08 | — | — | US | disclosed |
| WO-2008080965-A2 | HIV INHIBITING 5,6-SUBSTITUTED PYRIMIDINES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012092-A1 | Hiv Inhibiting 1,2,4-Triazin-6-One Derivatives | NCOR1, NR1H3, NCOA3 | GABRA1 1960/4885GABRG2 3295/4885GABRB3 1131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.