Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 5/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4173358 | 0.92 | RAF1 (0.52) | RAF1MAPTRETKDRPLK4 | |
| SCHEMBL4181174 | 0.90 | RET (0.56) | RAF1RETBRAFKDRCDK8 | |
| SCHEMBL257963 | 0.82 | RAF1 (0.59) | RAF1RETBRAFKDRCDK8 | |
| SCHEMBL938402 | 0.78 | RAF1 (0.58) | RAF1MAPTBRAFKDRALDH1A1 | |
| SCHEMBL261957 | 0.76 | MAPT (0.49) | RAB9ANPC1MAPTALDH1A1KDM4E | |
| SCHEMBL1395927 | 0.76 | RAF1 (0.68) | RAF1RETBRAFKDRCDK8 | |
| SCHEMBL16990709 | 0.75 | ALDH1A1 (0.46) | RAB9ANPC1ALDH1A1KDM4EMEN1 | |
| SCHEMBL939310 | 0.74 | ALDH1A1 (0.46) | RAF1MAPTBRAFKDRALDH1A1 | |
| SCHEMBL4185779 | 0.74 | RAF1 (0.58) | RAB9ANPC1RAF1BRAFKDR | |
| SCHEMBL12749714 | 0.74 | MEN1 (0.47) | RAF1KDRKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928239-B2 | Anticarcinogenic agents | BAYER HEALTHCARE LLC (US) | 2011-04-19 | — | — | US | disclosed |
| US-7928239-B2 | Anticarcinogenic agents | BAYER HEALTHCARE LLC (US) | 2011-04-19 | — | — | US | disclosed |