Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 15/20 | 0.66 |
| ▸ | ABL1 | P00519 | 4/20 | 0.66 |
| ▸ | INSR | P06213 | 4/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.66 |
| ▸ | CDK2 | P24941 | 4/20 | 0.66 |
| ▸ | PLK1 | P53350 | 3/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3326173 | 0.92 | EGFR (0.68) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL3320362 | 0.92 | EGFR (0.72) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL142111 | 0.91 | EGFR (0.68) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL142106 | 0.91 | EGFR (0.79) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL29387336 | 0.91 | EGFR (0.79) | EGFRERBB2ABL1INSRPDGFRB | |
| Hydrochloric Acid SCHEMBL2511570 | 0.90 | EGFR (0.78) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL3004266 | 0.89 | EGFR (0.70) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL4087313 | 0.86 | EGFR (0.68) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL2700937 | 0.86 | EGFR (0.59) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL138668 | 0.85 | ABCB11 (0.78) | EGFRERBB2ABL1INSRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011039759-A1 | A NEW PROCESS FOR THE PREPARATION OF LAPATINIB AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS | NATCO PHARMA LIMITED (IN) | 2011-04-07 | — | — | WO | disclosed |
| WO-2008024439-A2 | 4-AMINOQUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF | CONCERT PHARMACEUTICALS INC. (US) | 2008-02-28 | — | — | WO | disclosed |