Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL9 | O00512 | 1/20 | 0.51 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL3720210 | 1.00 | BCL9 (0.51) | BCL9CTNNB1GAASRD5A2ALDH1A1 | |
| SCHEMBL27544786 | 0.98 | BCL9 (0.50) | BCL9CTNNB1GAASRD5A2ALDH1A1 | |
| Dioxane SCHEMBL8029153 | 0.94 | GAA (0.53) | BCL9CTNNB1GAASRD5A2ALDH1A1 | |
| Cyclohexane SCHEMBL30739999 | 0.89 | GAA (0.57) | BCL9CTNNB1GAASRD5A2ALDH1A1 | |
| SCHEMBL26375 | 0.87 | GAA (0.62) | BCL9CTNNB1GAASRD5A2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7895039 | 0.85 | GAA (0.61) | BCL9CTNNB1GAASRD5A2ALDH1A1 | |
| Bicarbonate SCHEMBL7985678 | 0.85 | GAA (0.61) | BCL9CTNNB1GAASRD5A2ALDH1A1 | |
| Bromide SCHEMBL30468845 | 0.85 | GAA (0.61) | BCL9CTNNB1GAASRD5A2ALDH1A1 | |
| Cyclopentene SCHEMBL31370853 | 0.83 | GAA (0.51) | BCL9CTNNB1GAASRD5A2ALDH1A1 | |
| Bicarbonate SCHEMBL9330234 | 0.82 | GAA (0.57) | BCL9CTNNB1GAASRD5A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104918945-A | Tricyclic fused thiophene derivatives as JAK inhibitors | INCYTE CORP | 2015-09-16 | — | — | CN | disclosed |
| WO-2011017395-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-02-10 | — | — | WO | disclosed |
| WO-2010135424-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-11-25 | — | — | WO | disclosed |