Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.57 |
| ▸ | BCL9 | O00512 | 1/20 | 0.57 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | CES1 | P23141 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MGLL | Q99685 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26375 | 0.98 | GAA (0.62) | GAASRD5A2BCL9CTNNB1KMT2A | |
| Hydrochloric Acid SCHEMBL7895039 | 0.96 | GAA (0.61) | GAASRD5A2BCL9CTNNB1KMT2A | |
| Bromide SCHEMBL30468845 | 0.96 | GAA (0.61) | GAASRD5A2BCL9CTNNB1KMT2A | |
| Acetic Acid SCHEMBL28965273 | 0.92 | GAA (0.62) | GAASRD5A2BCL9CTNNB1KMT2A | |
| Cyclohexane SCHEMBL30739999 | 0.92 | GAA (0.57) | GAASRD5A2BCL9CTNNB1KMT2A | |
| SCHEMBL26654348 | 0.92 | GAA (0.57) | GAASRD5A2BCL9CTNNB1KMT2A | |
| Bicarbonate SCHEMBL9330234 | 0.92 | GAA (0.57) | GAASRD5A2BCL9CTNNB1KMT2A | |
| SCHEMBL7196972 | 0.91 | GAA (0.60) | GAASRD5A2BCL9CTNNB1KMT2A | |
| Ethylene Glycol SCHEMBL5476136 | 0.91 | BCL9 (0.57) | GAASRD5A2BCL9CTNNB1KMT2A | |
| SCHEMBL27421509 | 0.90 | ALOX5 (0.60) | GAASRD5A2BCL9CTNNB1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265418-B1 | ANTICOAGULANTS | UBE INDUSTRIES, LTD. (JP) | 2001-07-24 | — | — | US | disclosed |