Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.50 |
| ▸ | BCL9 | O00512 | 1/20 | 0.50 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL3720210 | 0.94 | BCL9 (0.51) | GAASRD5A2BCL9CTNNB1KMT2A | |
| Tetrahydrofuran SCHEMBL1273145 | 0.94 | BCL9 (0.51) | GAASRD5A2BCL9CTNNB1KMT2A | |
| SCHEMBL27544786 | 0.92 | BCL9 (0.50) | GAASRD5A2BCL9CTNNB1KMT2A | |
| SCHEMBL26375 | 0.89 | GAA (0.62) | GAASRD5A2BCL9CTNNB1KMT2A | |
| Cyclohexane SCHEMBL30739999 | 0.88 | GAA (0.57) | GAASRD5A2BCL9CTNNB1KMT2A | |
| Bromide SCHEMBL30468845 | 0.88 | GAA (0.61) | GAASRD5A2BCL9CTNNB1KMT2A | |
| Bicarbonate SCHEMBL7985678 | 0.88 | GAA (0.61) | GAASRD5A2BCL9CTNNB1KMT2A | |
| Hydrochloric Acid SCHEMBL7895039 | 0.88 | GAA (0.61) | GAASRD5A2BCL9CTNNB1KMT2A | |
| Bicarbonate SCHEMBL9330234 | 0.84 | GAA (0.57) | GAASRD5A2BCL9CTNNB1KMT2A | |
| SCHEMBL26654348 | 0.84 | GAA (0.57) | GAASRD5A2BCL9CTNNB1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127372-A | FOR TREATMENT OR PREVENTION OF VIRAL DISEASES, ESPECIALLY AIDS OR HIV | VERTEX PHARMACEUTICALS, INCORPORATED (US) | 2000-10-03 | — | — | US | disclosed |
| EP-0749421-B1 | SULPHONAMIDE DERIVATIVES AS ASPARTYL PROTEASE INHIBITORS | VERTEX PHARMA (US) | 1999-09-15 | — | — | EP | disclosed |
| EP-0749421-A1 | SULPHONAMIDE DERIVATIVES AS ASPARTYL PROTEASE INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 1996-12-27 | — | — | EP | disclosed |
| WO-1995024385-A1 | SULPHONAMIDE DERIVATIVES AS ASPARTYL PROTEASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1995-09-14 | — | — | WO | disclosed |