Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 9/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1272783 | 1.00 | HDAC8 (0.49) | HDAC8MCL1ABCB1HTRA1TACR1 | |
| SCHEMBL1273334 | 0.85 | POLB (0.55) | HDAC8HTRA1TACR1MEN1POLB | |
| SCHEMBL18573054 | 0.84 | HDAC8 (0.54) | HDAC8MCL1HTRA1TACR1POLB | |
| SCHEMBL8303540 | 0.82 | ABCB1 (0.46) | HDAC8MCL1ABCB1ALDH1A1HPGD | |
| SCHEMBL8300804 | 0.82 | ABCB1 (0.46) | HDAC8MCL1ABCB1ALDH1A1HPGD | |
| SCHEMBL8303542 | 0.82 | ABCB1 (0.46) | HDAC8MCL1ABCB1ALDH1A1HPGD | |
| SCHEMBL6945215 | 0.81 | ABCB1 (0.51) | MCL1ABCB1HTRA1POLBCYP3A4 | |
| SCHEMBL6945211 | 0.81 | ABCB1 (0.51) | MCL1ABCB1HTRA1POLBCYP3A4 | |
| SCHEMBL13164549 | 0.81 | ABCB1 (0.52) | HDAC8MCL1ABCB1PTPN1CYP3A4 | |
| SCHEMBL7279809 | 0.80 | ABCB1 (0.51) | HDAC8MCL1ABCB1HTRA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110034469-A1 | Heterocyclic Compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034469-A1 | Heterocyclic Compound | BIRC5, XIAP, BIRC2 | HDAC8 558/4885MCL1 237/4885ABCB1 1821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.