SCHEMBL12760880

SCHEMBL12760880

CC(C)(C)C(=C(O)C(=O)OCC(COC(=O)C(O)=C(c1ccccc1C(C)(C)C)C(C)(C)C)(COC(=O)C(O)=C(c1ccccc1C(C)(C)C)C(C)(C)C)COC(=O)C(O)=C(c1ccccc1C(C)(C)C)C(C)(C)C)c1ccccc1C(C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.41
HIF1A Q16665 1/20 0.41
TDP1 Q9NUW8 2/20 0.37
ATM Q13315 1/20 0.37
ALDH1A1 P00352 4/20 0.35
KDM4E B2RXH2 2/20 0.35
GAA P10253 1/20 0.35
RXRA P19793 1/20 0.35
RXRB P28702 1/20 0.35
RXRG P48443 1/20 0.35
RBP4 P02753 3/20 0.33
NPC1 O15118 1/20 0.33
RECQL P46063 1/20 0.33
RAB9A P51151 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
TSHR P16473 2/20 0.33
NR1H4 Q96RI1 1/20 0.32
NLRP3 Q96P20 1/20 0.32
ELANE P08246 2/20 0.32
HSD11B1 P28845 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31098923 1.00 MAPK1 (0.41) MAPK1HIF1ATDP1ATMALDH1A1
SCHEMBL31238580 0.84 MAPK1 (0.36) MAPK1HIF1ATDP1ATMALDH1A1
SCHEMBL30482826 0.79 RBP4 (0.43) TDP1ATMALDH1A1KDM4EGAA
SCHEMBL15366984 0.79 RBP4 (0.43) TDP1ATMALDH1A1KDM4EGAA
SCHEMBL30482829 0.79 RBP4 (0.43) TDP1ATMALDH1A1KDM4EGAA
SCHEMBL28261658 0.70 MAPT (0.51) MAPK1TDP1ATMALDH1A1GAA
SCHEMBL39249 0.68 ALDH1A1 (0.56) TDP1ALDH1A1KDM4ERXRARXRB
SCHEMBL31028133 0.68 ALDH1A1 (0.56) TDP1ALDH1A1KDM4ERXRARXRB
Benzene SCHEMBL27468891 0.67 TSHR (0.65) MAPK1TDP1ALDH1A1KDM4ETSHR
SCHEMBL1787314 0.66 TSHR (0.69) MAPK1TDP1ALDH1A1KDM4ENPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9877900-B2 Use of cosmetics against infrared radiation COTY GERMANY GMBH (DE) 2018-01-30 US disclosed
EP-2178491-B1 MIXTURES COMPRISING BENZOTRIAZOLES AND MEROCYANINES BASF SE (DE) 2017-03-22 EP disclosed
US-9579267-B2 Cosmetic with enhanced collagen I synthesis COTY GERMANY GMBH (DE) 2017-02-28 US disclosed
US-9572768-B2 Cosmetic composition for use in increasing the collagen synthesis in skin cells COTY GERMANY GMBH (DE) 2017-02-21 US disclosed
EP-2731580-B1 USE OF COSMETICS AGAINST INFRARED RADIATION COTY GERMANY GMBH (DE) 2016-09-14 EP disclosed
EP-2731579-B1 COSMETIC WITH ENHANCED COLLAGEN I SYNTHESIS COTY GERMANY GMBH (DE) 2015-03-25 EP disclosed
EP-2505185-B1 Composition with improved tanning effect COTY GERMANY GMBH (DE) 2015-03-25 EP disclosed
US-8986718-B2 Composition with improved tanning effect COTY GERMANY GMBH (DE) 2015-03-24 US disclosed
US-20140161855-A1 COSMETIC WITH ENHANCED COLLAGEN I SYNTHESIS Monsanto Technology LLC a corporation (US) 2014-06-12 US disclosed
US-20140154191-A1 USE OF COSMETICS AGAINST INFRARED RADIATION COTY GERMANY GMBH (DE) 2014-06-05 US disclosed
EP-2731579-A2 COSMETIC WITH ENHANCED COLLAGEN I SYNTHESIS Coty Germany GmbH (DE) 2014-05-21 EP disclosed
US-20140127286-A1 COSMETIC COMPOSITION FOR USE IN INCREASING THE COLLAGEN SYNTHESIS IN SKIN CELLS COTY GERMANY GMBH (DE) 2014-05-08 US disclosed
WO-2013007827-A2 COSMETIC WITH ENHANCED COLLAGEN I SYNTHESIS COTY GERMANY GMBH (DE) 2013-01-17 WO disclosed
EP-2545898-A1 Use of cosmetics against infrared radiation COTY GERMANY GMBH (DE) 2013-01-16 EP disclosed
EP-2514403-A1 Cosmetic composition for increasing the collagen synthesis in the skin cells Coty Germany GmbH (DE) 2012-10-24 EP disclosed
US-20120251602-A1 COMPOSITION WITH IMPROVED TANNING EFFECT COTY GERMANY GMBH (DE) 2012-10-04 US disclosed
EP-2505185-A1 Composition with improved tanning effect COTY GERMANY GMBH (DE) 2012-10-03 EP disclosed