Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | AR | P10275 | 1/20 | 0.52 |
| ▸ | CCR2 | P41597 | 3/20 | 0.51 |
| ▸ | PGR | P06401 | 2/20 | 0.50 |
| ▸ | GCK | P35557 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6014834 | 0.82 | RAB9A (0.67) | NPC1SMN1; SMN2TSHRRAB9AKDM4E | |
| SCHEMBL12762202 | 0.80 | MAPT (0.55) | NPC1SMN1; SMN2TSHRRAB9AKDM4E | |
| SCHEMBL8737301 | 0.79 | FFAR1 (0.69) | NPC1SMN1; SMN2TSHRRAB9AKDM4E | |
| SCHEMBL6014761 | 0.79 | NPC1 (0.67) | NPC1SMN1; SMN2TSHRRAB9AKDM4E | |
| SCHEMBL13306317 | 0.77 | PGR (0.71) | NPC1SMN1; SMN2TSHRRAB9AKDM4E | |
| SCHEMBL9926370 | 0.77 | NPC1 (0.64) | NPC1SMN1; SMN2TSHRRAB9AKDM4E | |
| SCHEMBL14319827 | 0.77 | RAF1 (0.51) | NPC1SMN1; SMN2TSHRRAB9AKDM4E | |
| SCHEMBL21345908 | 0.76 | NPC1 (0.80) | NPC1SMN1; SMN2TSHRRAB9AGCK | |
| SCHEMBL15474235 | 0.74 | NPC1 (0.76) | NPC1SMN1; SMN2TSHRRAB9AKDM4E | |
| SCHEMBL6014847 | 0.73 | KMT2A (0.65) | NPC1SMN1; SMN2TSHRRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897623-B2 | FDA Orange book listed patent for sorafenib tosylate; tablets | BAYER HEALTHCARE LLC (US) | 2011-03-01 | — | — | US | disclosed |
| US-7897623-B2 | FDA Orange book listed patent for sorafenib tosylate; tablets | BAYER HEALTHCARE LLC (US) | 2011-03-01 | — | — | US | disclosed |
| US-20080027061-A1 | omega-Carboxy Aryl Substituted Diphenyl Ureas As p38 Kinase Inhibitors | BAYER HEALTHCARE LLC | 2008-01-31 | — | — | US | disclosed |
| US-20080027061-A1 | omega-Carboxy Aryl Substituted Diphenyl Ureas As p38 Kinase Inhibitors | BAYER HEALTHCARE LLC | 2008-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027061-A1 | omega-Carboxy Aryl Substituted Diphenyl Ureas As p38 Kinase Inhibitors | MAPK1, MAPK8, MAPK3 | NPC1 569/4885SMN1; SMN2 2811/4885TSHR 3645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.