Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Eniluracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPYD known ✓ | Q12882 | 3/20 | 0.65 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376391 | 0.86 | ATAD2 (0.47) | DPYDATAD2 | |
| Eniluracil SCHEMBL37817 | 0.80 | DPYD (1.00) | DPYDATAD2ALDH1A1 | |
| SCHEMBL30847882 | 0.72 | ATAD2 (0.40) | DPYDATAD2 | |
| SCHEMBL29007135 | 0.69 | KMT2A (0.54) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4273200 | 0.69 | ATAD2 (0.44) | ATAD2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11147060 | 0.69 | ATAD2 (0.44) | ATAD2 | |
| SCHEMBL29756976 | 0.69 | DPYD (0.43) | DPYD | |
| Eniluracil SCHEMBL5392934 | 0.69 | DPYD (0.73) | DPYDATAD2ALDH1A1 | |
| SCHEMBL30716110 | 0.69 | GAA (0.47) | DPYDATAD2ALDH1A1 | |
| SCHEMBL2043942 | 0.69 | DPYD (0.52) | DPYDATAD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8409802-B2 | Format of probes to detect nucleic acid differences | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2013-04-02 | — | — | US | disclosed |
| US-20110039264-A1 | Format of Probes to Detect Nucleic Acid Differences | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2011-02-17 | — | — | US | disclosed |