Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VIP | P01282 | 2/20 | 0.49 |
| ▸ | KCNA6 | P17658 | 1/20 | 0.48 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.48 |
| ▸ | KCNA4 | P22459 | 1/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1518416 | 0.99 | VIP (0.48) | VIPKCNA6KCNA3KCNA4KCNA5 | |
| SCHEMBL12597850 | 0.83 | MAP2K1 (0.47) | KCNA6KCNA3KCNA4KCNA5DAO | |
| SCHEMBL12648622 | 0.82 | VIP (0.40) | VIPKCNA6KCNA3KCNA4KCNA5 | |
| Hydrochloric Acid SCHEMBL1518077 | 0.82 | MAP2K1 (0.47) | KCNA6KCNA3KCNA4KCNA5DAO | |
| Hydrochloric Acid SCHEMBL1523384 | 0.82 | VIP (0.39) | VIPKCNA6KCNA3KCNA4KCNA5 | |
| SCHEMBL14114459 | 0.81 | KCNA6 (0.36) | VIPKCNA6KCNA3KCNA4KCNA5 | |
| Hydrochloric Acid SCHEMBL1518215 | 0.79 | HDAC3 (0.49) | SCN9ASCN3ASCN5A | |
| Hydrochloric Acid SCHEMBL1518116 | 0.77 | KCNA6 (0.46) | KCNA6KCNA3KCNA4KCNA5DAO | |
| Hydrochloric Acid SCHEMBL1518217 | 0.77 | CBLB (0.39) | PKMALDH1A1 | |
| Dihydrosventrin SCHEMBL12559819 | 0.75 | CBLB (0.38) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422404-B2 | 2-aminoimidazole-functional silicone compositions and methods of making the same | DOW CORNING CORPORATION (US) | 2016-08-23 | — | — | US | disclosed |
| US-20160024257-A1 | 2-Aminoimidazole-Functional Silicone Compositions And Methods Of Making The Same | DOW SILICONES CORPORATION | 2016-01-28 | — | — | US | disclosed |
| US-9084423-B2 | Inhibition of bacterial biofilms with imidazole derivatives | NORTH CAROLINA STATE UNIVERSITY (US) | 2015-07-21 | — | — | US | disclosed |
| US-20140127273-A1 | INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY (US) | 2014-05-08 | — | — | US | disclosed |
| US-8653124-B2 | Inhibition of bacterial biofilms with imidazole derivatives | NORTH CAROLINA STATE UNIVERSITY (US) | 2014-02-18 | — | — | US | disclosed |
| US-7906544-B2 | Dentifrices; stents; catheters; grafts | NORTH CAROLINA STATE UNIVERSITY (US) | 2011-03-15 | — | — | US | disclosed |
| US-7906544-B2 | Dentifrices; stents; catheters; grafts | NORTH CAROLINA STATE UNIVERSITY (US) | 2011-03-15 | — | — | US | disclosed |
| WO-2008094479-A1 | INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY (US) | 2008-08-07 | — | — | WO | disclosed |
| US-20080181923-A1 | INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY | 2008-07-31 | — | — | US | disclosed |
| US-20080181923-A1 | INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY | 2008-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080181923-A1 | INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES | O60361, TFPI, BLVRB | VIP 731/4885KCNA6 2338/4885KCNA3 2208/4885 |
| US-20140127273-A1 | INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES | O60361, TFPI, BLVRB | VIP 731/4885KCNA6 2338/4885KCNA3 2208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.