Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methacycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 11/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.70 |
| ▸ | RECQL | P46063 | 7/20 | 0.70 |
| ▸ | HPGD | P15428 | 7/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.70 |
| ▸ | MEN1 | O00255 | 6/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.70 |
| ▸ | THRB | P10828 | 5/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.70 |
| ▸ | RAD52 | P43351 | 1/20 | 0.70 |
| ▸ | USP2 | O75604 | 7/20 | 0.69 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | MC4R | P32245 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacycline SCHEMBL127703 | 1.00 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL5445227 | 1.00 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL30582540 | 1.00 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL2614978 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL29376851 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL17430778 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL5523818 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL19771282 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL21133469 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL13328119 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3108 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120067822-A | Automatic identification method, system, equipment and medium for part geometric modification | 成都飞机工业（集团）有限责任公司 | 2025-05-30 | — | — | CN | claimed |
| CN-222678016-U | Mother liquor neutralization tank for metacycline hydrochloride | 镇江高海生物药业有限公司 | 2025-03-28 | — | — | CN | claimed |
| CN-222630171-U | Waste liquid collecting cylinder based on metacycline hydrochloride production | 镇江高海生物药业有限公司 | 2025-03-18 | — | — | CN | claimed |
| CN-119107754-A | Disaster prevention emergency rescue method based on submarine tunnel construction period | 重庆大学 | 2024-12-10 | — | — | CN | claimed |
| CN-118962607-A | Multi-wave-level multi-mode rapid radiation calibration method based on tropical rain forest | 中国电子科技集团公司第三十八研究所 | 2024-11-15 | — | — | CN | claimed |
| CN-118642489-A | On-line spiral coverage path planning method for self-adaptive direction adjustment in unknown environment | 湖南第一师范学院 | 2024-09-13 | — | — | CN | claimed |
| CN-118427887-A | Distributed database remote integrity auditing method and system supporting multi-cloud server collaboration | 武汉大学 | 2024-08-02 | — | — | CN | claimed |
| CN-118348352-A | Novel power distribution network line lightning risk early warning method based on time reversal | 广西电网有限责任公司电力科学研究院 | 2024-07-16 | — | — | CN | claimed |
| CN-114152268-B | Inertial navigation energy verification system for missile-borne test | 北京控制工程研究所 | 2024-05-31 | — | — | CN | claimed |
| CN-220950188-U | Airflow conveyer for methacycline hydrochloride | 镇江高海生物药业有限公司 | 2024-05-14 | — | — | CN | claimed |
| EP-1119345-A1 | ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES | GENERAL MILLS, INC. (US) | 2001-08-01 | — | — | EP | claimed |
| WO-2000021504-A1 | ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES | GENERAL MILLS, INC. (US) | 2000-04-20 | — | — | WO | claimed |
| EP-0935523-A4 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GEN MILLS INC (US) | 1999-12-29 | — | — | EP | claimed |
| US-5948416-A | LEAVE ON SKIN CARE COMPOSITION; HYDROPHOBIC STRUCTURING AGENT; HYDROPHILIC CATIONIC SURFACTANT; ACTIVE COMPOUND | THE PROCTER & GAMBLE COMPANY (US) | 1999-09-07 | — | — | US | claimed |
| EP-0935523-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GENERAL MILLS, INC. (US) | 1999-08-18 | — | — | EP | claimed |
| US-5780049-A | Enhanced skin penetration system for improved topical delivery of drugs | RICHARDSON-VICKS INC. (US) | 1998-07-14 | — | — | US | claimed |
| WO-1998018610-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | LENGERICH BERNHARD H VAN (US) | 1998-05-07 | — | — | WO | claimed |
| EP-0736302-A2 | Protease inhibitors, a DNA construct for the expression of a protease and a process for measuring proteases and/or protease inhibitors | Stichting REGA V.Z.W. (BE) | 1996-10-09 | — | — | EP | claimed |
| EP-0733369-A1 | Protease inhibitors, a DNA construct for the expression of a protease and a process for measuring proteases and/or protease inhibitors | Stichting REGA V.Z.W. (BE) | 1996-09-25 | — | — | EP | claimed |
| US-3966808-A | HALOGENATION, DEHYDRATION, METHACYCLINE HYDROCHLORIDE | RACHELLE LABORATORIES ITALIA, S.P.A. (IT) | 1976-06-29 | — | — | US | claimed |