Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methacycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 11/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.70 |
| ▸ | RECQL | P46063 | 7/20 | 0.70 |
| ▸ | HPGD | P15428 | 7/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.70 |
| ▸ | MEN1 | O00255 | 6/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.70 |
| ▸ | THRB | P10828 | 5/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.70 |
| ▸ | RAD52 | P43351 | 1/20 | 0.70 |
| ▸ | USP2 | O75604 | 7/20 | 0.69 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | MC4R | P32245 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacycline SCHEMBL5445227 | 1.00 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL127702 | 1.00 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL30582540 | 1.00 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL2614978 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL29376851 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL17430778 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL5523818 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL19771282 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL21133469 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL13328119 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2593 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-220950188-U | Airflow conveyer for methacycline hydrochloride | 镇江高海生物药业有限公司 | 2024-05-14 | — | — | CN | claimed |
| CN-220750646-U | Methylene terramycin hydrochloride stoving vacuum drier | 镇江高海生物药业有限公司 | 2024-04-09 | — | — | CN | claimed |
| CN-220573393-U | Swing type granulator for producing methacycline hydrochloride | 镇江高海生物药业有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-220573430-U | Methyleneoxytetracycline hydrochloride production mother liquor neutralization tank | 镇江高海生物药业有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117023746-A | Treatment system for waste liquid generated in production of methacycline hydrochloride and application method of treatment system | 镇江高海生物药业有限公司 | 2023-11-10 | — | — | CN | claimed |
| CN-110975881-B | Dechlorination catalyst for synthesizing metacycline hydrochloride and preparation method and application thereof | 扬州联博药业有限公司 | 2023-03-10 | — | — | CN | claimed |
| CN-114713193-A | Nitrogen-doped magnetic porous carbon composite material and preparation method and application thereof | 华南师范大学 | 2022-07-08 | — | — | CN | claimed |
| US-20220169680-A1 | CELL-PENETRATING PEPTIDE BASED ON INFLUENZA VIRUS M2 PROTEIN | INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2022-06-02 | — | — | US | claimed |
| EP-3912989-A1 | CELL-PENETRATING PEPTIDE BASED ON INFLUENZA VIRUS M2 PROTEIN | Institute of Basic Medical Sciences Chinese Academy of Medical Sciences (CN) | 2021-11-24 | — | — | EP | claimed |
| CN-112912386-A | Cell penetrating peptide based on influenza virus M2 protein | 中国医学科学院基础医学研究所 | 2021-06-04 | — | — | CN | claimed |
| US-20020044968-A1 | High amount of plasticizer to facilitate plasticization of the matrix material at low shear and then reduced prior to adding the encapsulant to reduce post extrusion | GENERAL MILLS, INC. | 2002-04-18 | — | — | US | claimed |
| JP-2002511777-A | — | — | 2002-04-16 | — | — | JP | claimed |
| EP-1119345-A1 | ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES | GENERAL MILLS, INC. (US) | 2001-08-01 | — | — | EP | claimed |
| WO-2000021504-A1 | ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES | GENERAL MILLS, INC. (US) | 2000-04-20 | — | — | WO | claimed |
| EP-0935523-A4 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GEN MILLS INC (US) | 1999-12-29 | — | — | EP | claimed |
| US-5948416-A | LEAVE ON SKIN CARE COMPOSITION; HYDROPHOBIC STRUCTURING AGENT; HYDROPHILIC CATIONIC SURFACTANT; ACTIVE COMPOUND | THE PROCTER & GAMBLE COMPANY (US) | 1999-09-07 | — | — | US | claimed |
| EP-0935523-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GENERAL MILLS, INC. (US) | 1999-08-18 | — | — | EP | claimed |
| US-5780049-A | Enhanced skin penetration system for improved topical delivery of drugs | RICHARDSON-VICKS INC. (US) | 1998-07-14 | — | — | US | claimed |
| WO-1998018610-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | LENGERICH BERNHARD H VAN (US) | 1998-05-07 | — | — | WO | claimed |
| US-3966808-A | HALOGENATION, DEHYDRATION, METHACYCLINE HYDROCHLORIDE | RACHELLE LABORATORIES ITALIA, S.P.A. (IT) | 1976-06-29 | — | — | US | claimed |