Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Methacycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 11/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.70 |
| ▸ | RECQL | P46063 | 7/20 | 0.70 |
| ▸ | HPGD | P15428 | 7/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.70 |
| ▸ | MEN1 | O00255 | 6/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.70 |
| ▸ | THRB | P10828 | 5/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.70 |
| ▸ | RAD52 | P43351 | 1/20 | 0.70 |
| ▸ | USP2 | O75604 | 7/20 | 0.69 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | MC4R | P32245 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacycline SCHEMBL127703 | 1.00 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL127702 | 1.00 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL30582540 | 1.00 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL2614978 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL29376851 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL17430778 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL5523818 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL19771282 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL21133469 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 | |
| Methacycline SCHEMBL13328119 | 0.99 | TDP1 (0.70) | TDP1KDM4ERECQLHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10095524-B2 | Method and apparatus for dynamically replacing legacy instructions with a single executable instruction utilizing a wide datapath | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2018-10-09 | — | — | US | disclosed |
| US-20150082009-A1 | METHOD AND APPARATUS FOR THE DYNAMIC CREATION OF INSTRUCTIONS UTILIZING A WIDE DATAPATH | INTERNATIONAL BUSINESS MACHINES CORPORATION | 2015-03-19 | — | — | US | disclosed |
| US-8904151-B2 | Method and apparatus for the dynamic identification and merging of instructions for execution on a wide datapath | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2014-12-02 | — | — | US | disclosed |
| US-20070260855-A1 | Method and apparatus for the dynamic creation of instructions utilizing a wide datapath | INTERNATIONAL BUSINESS MACHINES CORPORATION | 2007-11-08 | — | — | US | disclosed |