SCHEMBL127726

SCHEMBL127726

CCCCC[CH]OCCC

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.40
LPAR3 Q9UBY5 1/20 0.36
FAAH O00519 3/20 0.36
TRPV1 Q8NER1 1/20 0.36
TERT O14746 3/20 0.35
PTPN1 P18031 3/20 0.35
MAPT P10636 2/20 0.35
BLM P54132 2/20 0.35
HSD17B10 Q99714 2/20 0.35
FABP4 P15090 2/20 0.35
PPARG P37231 2/20 0.35
PPARD Q03181 2/20 0.35
PPARA Q07869 2/20 0.35
GMNN O75496 1/20 0.35
USP2 O75604 1/20 0.35
LMNA P02545 1/20 0.35
CYP1A2 P05177 1/20 0.35
POLB P06746 1/20 0.35
CYP2C9 P11712 1/20 0.35
ALOX15 P16050 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL816236 0.97 TSHR (0.44) TSHRFAAHTRPV1TERTPTPN1
SCHEMBL817634 0.97 TSHR (0.44) TSHRFAAHTRPV1TERTPTPN1
SCHEMBL816463 0.97 TSHR (0.44) TSHRFAAHTRPV1TERTPTPN1
SCHEMBL815521 0.97 TSHR (0.44) TSHRFAAHTRPV1TERTPTPN1
SCHEMBL815515 0.97 TSHR (0.44) TSHRFAAHTRPV1TERTPTPN1
SCHEMBL817359 0.97 TSHR (0.44) TSHRFAAHTRPV1TERTPTPN1
SCHEMBL980997 0.97 TSHR (0.44) TSHRFAAHTRPV1TERTPTPN1
SCHEMBL817299 0.97 TSHR (0.44) TSHRFAAHTRPV1TERTPTPN1
SCHEMBL816919 0.97 TSHR (0.44) TSHRFAAHTRPV1TERTPTPN1
SCHEMBL817952 0.97 TSHR (0.44) TSHRFAAHTRPV1TERTPTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 461 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11548900-B2 Oxazino-quinazoline and oxazino-quinoline type compound, preparation method and uses thereof BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) 2023-01-10 US claimed
EP-3760633-B1 OXAZINO-QUINAZOLINE AND OXAZINO-QUINAZOLINE TYPE COMPOUND, PREPARATION METHOD THEREFOR, AND USES THEREOF BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN) 2021-12-15 EP claimed
US-11091474-B2 Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation UCB Biopharma SRL (BE) 2021-08-17 US claimed
CN-110229171-B Oxazinoquinazoline and oxazinoquinoline compound and preparation method and application thereof 北京赛特明强医药科技有限公司 2021-03-12 CN claimed
US-20210040114-A1 OXAZINO-QUINAZOLINE AND OXAZINO-QUINOLINE TYPE COMPOUND, PREPARATION METHOD AND USES THEREOF ACCSALUS BIOSCIENCES LIMITED (VG) 2021-02-11 US claimed
EP-3760633-A1 OXAZINO-QUINAZOLINE AND OXAZINO-QUINAZOLINE TYPE COMPOUND, PREPARATION METHOD THEREFOR, AND USES THEREOF Beijing Scitech-MQ Pharmaceuticals Limited (CN) 2021-01-06 EP claimed
CN-111718332-A 2-substituted pyrazol amino-4-substituted amino-5-pyrimidine formamide compound, composition and application thereof 北京赛特明强医药科技有限公司 2020-09-29 CN claimed
WO-2020187292-A1 2-SUBSTITUTED PYRAZOLEAMINO-4-SUBSTITUTED AMINO-5-PYRIMIDINE FORMAMIDE COMPOUND, COMPOSITION AND USE THEREOF 北京赛特明强医药科技有限公司 2020-09-24 WO claimed
US-20200291013-A1 ALKOXY BIS-HETEROARYL DERIVATIVES AS MODULATORS OF PROTEIN AGGREGATION UCB BIOPHARMA SPRL (BE) 2020-09-17 US claimed
CN-110229171-A A kind of oxazines and quinazoline and oxazines and quinolines and its preparation method and application 北京赛特明强医药科技有限公司 2019-09-13 CN claimed
CN-110191885-A ALKOXY BIS-HETEROARYL DERIVATIVES AS MODULATORS OF PROTEIN AGGREGATION UCB生物制药私人有限公司 2019-08-30 CN claimed
WO-2018138085-A1 ALKOXY BIS-HETEROARYL DERIVATIVES AS MODULATORS OF PROTEIN AGGREGATION UCB BIOPHARMA SPRL (BE) 2018-08-02 WO claimed
US-20030130398-A1 Soft polymeric compounds including metal oxide fillers BRIDGESTONE CORPORATION 2003-07-10 US claimed
US-6369166-B1 PLASTICIZED; TENSILE AND TEAR STRENGTH; ELONGATION; HIGH DAMPING; ETHYLENE-MALEIC ANHYDRIDE COPOLYMER REACTED WITH PRIMARY AMINE BRIDGESTONE CORPORATION (JP) 2002-04-09 US claimed
US-20010021743-A1 Method of producing a graft copolymer BRIDGESTONE CORPORATION (JP) 2001-09-13 US claimed
US-6207763-B1 A COPOLYMER OF SUBSTITUTED OR UNSUBSTITUTED 1-20 ALKYL GROUP DISUBSTITUTED ETHYLENE-MALEIMIDE COPOLYMER(A REACTION PRODUCT OF DISUBTITUTED ETHYLENE-MALEIC ANHYDRIDE IMIDIZED WITH PRIMARY AMINE) IS A PLASTICIZER FOR RUBBER; HIGH DAMPING BRIDGESTONE CORPORATION (JP) 2001-03-27 US claimed
US-6204354-B1 DRY ENVIRONMENT BRIDGESTONE CORPORATION (JP) 2001-03-20 US claimed
US-6191217-B1 REACTING POLY(ALKYL VINYLETHER-CO-MALEIMIDE) POLYMER WITH MALEATED POLYALKYLENE AND ALKYL DIAMINE UNDER SUBSTANTIALLY DRY CONDITIONS SUFFICIENT TO FORM POLYALKYLENE GRAFTED POLY(ALKYL VINYLETHER-CO-MALEIMIDE) POLYMER BRIDGESTONE CORPORATION (JP) 2001-02-20 US claimed
US-6133354-A MIXING A POLY(DIALKYLSUBSTITUTED ETHYLENE-CO-MALEIMIDE) POLYMER SUCH AS POLYISOBUTYLENE-CO-MALEIMIDE, AND PLASTICIZERS OR EXTENDERS WITHIN A NON-VULCANIZED THERMOPLASTIC ELASTOMER TO FORM A DAMPING GEL; TENSILE STRENGTH AND TEAR STRENGTH BRIDGESTONE CORPORATION (JP) 2000-10-17 US claimed
EP-0955319-A1 Soft compounds derived from polypropylene grafted disubstituted ethylene-maleimide copolymers Bridgestone Corporation (JP) 1999-11-10 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200291013-A1 ALKOXY BIS-HETEROARYL DERIVATIVES AS MODULATORS OF PROTEIN AGGREGATION PARK7, HTT, SNCA TSHR 3836/4885LPAR3 447/4885FAAH 2699/4885
US-11548900-B2 Oxazino-quinazoline and oxazino-quinoline type compound, preparation method and uses thereof WNK1, WNK2, WNK3 TSHR 4235/4885LPAR3 2830/4885FAAH 2485/4885
US-11091474-B2 Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation PARK7, HTT, SNCA TSHR 3836/4885LPAR3 447/4885FAAH 2699/4885
US-20210040114-A1 OXAZINO-QUINAZOLINE AND OXAZINO-QUINOLINE TYPE COMPOUND, PREPARATION METHOD AND USES THEREOF WNK1, WNK2, WNK3 TSHR 4235/4885LPAR3 2830/4885FAAH 2485/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.