Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | JUN | P05412 | 7/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 7/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 7/20 | 0.57 |
| ▸ | RELA | Q04206 | 7/20 | 0.57 |
| ▸ | FOS | P01100 | 5/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543216 | 0.92 | KDM4E (0.72) | KDM4EJUNNFKB1NFKB2RELA | |
| SCHEMBL21341724 | 0.90 | KDM4E (0.55) | KDM4EJUNNFKB1NFKB2RELA | |
| SCHEMBL5062196 | 0.89 | KDM4E (0.69) | KDM4EJUNNFKB1NFKB2RELA | |
| SCHEMBL423492 | 0.84 | JUN (0.60) | KDM4EJUNNFKB1NFKB2RELA | |
| SCHEMBL4425453 | 0.83 | JUN (0.59) | KDM4EJUNNFKB1NFKB2RELA | |
| SCHEMBL1013852 | 0.82 | KDM4E (0.56) | KDM4EJUNNFKB1NFKB2RELA | |
| SCHEMBL2354109 | 0.82 | KDM4E (0.67) | KDM4EJUNNFKB1NFKB2RELA | |
| SCHEMBL131646 | 0.82 | NFKB1 (0.58) | KDM4EJUNNFKB1NFKB2RELA | |
| SCHEMBL17393706 | 0.82 | JUN (0.58) | KDM4EJUNNFKB1NFKB2RELA | |
| SCHEMBL3283794 | 0.82 | JUN (0.58) | KDM4EJUNNFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902373-B2 | asthma; for treating prostaglandin D2 mediated diseases; e.g. 6-(3-fluorophenyl)-N-[1-(1-methyl-1H-tetrazol-5-yl)piperidin-4-yl]nicotinamide | PFIZER INC (US) | 2011-03-08 | — | — | US | disclosed |
| US-20080146569-A1 | Nicotinamide Derivatives | PFIZER INC. | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146569-A1 | Nicotinamide Derivatives | NNT, NAMPT, NADK | KDM4E 3026/4885JUN 3892/4885NFKB1 838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.