Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | DBH | P09172 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16114691 | 0.86 | MAPT (0.49) | HTTMAPTSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL3925418 | 0.86 | MAPT (0.49) | HTTMAPTSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL13547950 | 0.85 | CA2 (0.42) | HTTMAPTSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL74008 | 0.82 | CA2 (0.63) | ALDH1A1KDM4ECA2 | |
| SCHEMBL2600043 | 0.82 | MAPT (0.49) | HTTMAPTSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL28827352 | 0.82 | PTPN1 (0.39) | HTTMAPTSMN1; SMN2L3MBTL1ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL28367769 | 0.81 | MAPT (0.48) | HTTMAPTSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL12844280 | 0.79 | MAPT (0.53) | HTTMAPTSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL9917308 | 0.79 | CRHBP (0.47) | HTTMAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2500053 | 0.79 | MAPT (0.56) | HTTMAPTSMN1; SMN2L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902373-B2 | asthma; for treating prostaglandin D2 mediated diseases; e.g. 6-(3-fluorophenyl)-N-[1-(1-methyl-1H-tetrazol-5-yl)piperidin-4-yl]nicotinamide | PFIZER INC (US) | 2011-03-08 | — | — | US | disclosed |
| US-20080146569-A1 | Nicotinamide Derivatives | PFIZER INC. | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146569-A1 | Nicotinamide Derivatives | NNT, NAMPT, NADK | HTT 3053/4885MAPT 1563/4885SMN1; SMN2 1371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.