Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.30 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31119206 | 0.80 | PSMB8 (0.38) | PSMB8HTTCYP2A6CA1CA2 | |
| SCHEMBL1280127 | 0.79 | PSMB8 (0.37) | PSMB8HTTCYP2A6CA1CA2 | |
| SCHEMBL1281032 | 0.79 | PSMB8 (0.37) | PSMB8HTTCYP2A6CA1CA2 | |
| SCHEMBL31109647 | 0.79 | ELANE (0.41) | PSMB8HTTCYP2A6CA1CA2 | |
| SCHEMBL2794791 | 0.78 | PSMB8 (0.34) | PSMB8HTTCYP2A6CA1CA2 | |
| SCHEMBL14327805 | 0.78 | MAPT (0.38) | PSMB8HTTCYP2A6CA1CA2 | |
| SCHEMBL14761783 | 0.72 | PSMD14 (0.39) | — | |
| SCHEMBL12778285 | 0.72 | ACHE (0.43) | PSMB8TSHRRAB9AKDM4EALDH1A1 | |
| SCHEMBL12778292 | 0.71 | PSMB8 (0.44) | PSMB8HTTCYP2A6CA1CA2 | |
| Trifluoroacetic Acid SCHEMBL31109741 | 0.67 | MALT1 (0.42) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011050160-A1 | PHARMACEUTICALS, COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. (US) | 2011-04-28 | — | — | WO | disclosed |