Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 3/20 | 0.55 |
| ▸ | PRKACG | P22612 | 3/20 | 0.55 |
| ▸ | PRKACB | P22694 | 3/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 14/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | EP300 | Q09472 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12779486 | 0.87 | PRKACA (0.75) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL12779394 | 0.87 | PRKACA (0.47) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL12779384 | 0.82 | PRKACA (0.61) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL12779442 | 0.79 | ROCK1 (0.57) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL12779445 | 0.78 | PRKACA (0.60) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL1648217 | 0.78 | ROCK2 (0.67) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL1647650 | 0.77 | PRKACA (0.58) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL1648761 | 0.76 | ROCK2 (0.49) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL12779446 | 0.75 | PRKACA (0.62) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL1648061 | 0.74 | PRKACA (0.81) | PRKACAPRKACGPRKACBROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011050245-A1 | BICYCLIC HETEROARYLS AS KINASE INHIBITORS | FENG YANGBO (US) | 2011-04-28 | — | — | WO | disclosed |