Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 3/20 | 0.58 |
| ▸ | PRKACG | P22612 | 3/20 | 0.58 |
| ▸ | PRKACB | P22694 | 3/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 14/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12779445 | 0.91 | PRKACA (0.60) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL12779486 | 0.89 | PRKACA (0.75) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL1648761 | 0.86 | ROCK2 (0.49) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL12779384 | 0.85 | PRKACA (0.61) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL12779489 | 0.77 | PRKACA (0.55) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL1648238 | 0.77 | ROCK2 (0.51) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL1648061 | 0.76 | PRKACA (0.81) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL12779446 | 0.76 | PRKACA (0.62) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL23360848 | 0.74 | ROCK2 (0.58) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL1647834 | 0.74 | PRKACA (0.77) | PRKACAPRKACGPRKACBROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011050245-A1 | BICYCLIC HETEROARYLS AS KINASE INHIBITORS | FENG YANGBO (US) | 2011-04-28 | — | — | WO | disclosed |
| WO-2011050245-A1 | BICYCLIC HETEROARYLS AS KINASE INHIBITORS | FENG YANGBO (US) | 2011-04-28 | — | — | WO | disclosed |