Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.77 |
| ▸ | ROCK1 | Q13464 | 14/20 | 0.77 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.57 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | PRKACG | P22612 | 1/20 | 0.52 |
| ▸ | PRKACB | P22694 | 1/20 | 0.52 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1649561 | 0.87 | ROCK2 (1.00) | ROCK2ROCK1RXFP1MEN1KMT2A | |
| SCHEMBL12779204 | 0.87 | ROCK2 (0.79) | ROCK2ROCK1RXFP1MEN1KMT2A | |
| SCHEMBL12779549 | 0.82 | ROCK2 (1.00) | ROCK2ROCK1MEN1KMT2APRKACA | |
| SCHEMBL1649557 | 0.80 | ROCK1 (0.76) | ROCK2ROCK1HSD17B2PRKACAABHD6 | |
| SCHEMBL12779736 | 0.76 | ROCK2 (0.80) | ROCK2ROCK1PRKACAPRKACGPRKACB | |
| SCHEMBL1647585 | 0.75 | ROCK1 (0.78) | ROCK2ROCK1HSD17B2ABHD6 | |
| SCHEMBL1647157 | 0.75 | ROCK2 (1.00) | ROCK2ROCK1PRKACAPRKACGPRKACB | |
| SCHEMBL12779734 | 0.74 | ROCK2 (0.79) | ROCK2ROCK1PRKACAPRKACGPRKACB | |
| SCHEMBL12495934 | 0.73 | HSD17B2 (1.00) | ROCK2ROCK1MEN1KMT2AHSD17B2 | |
| SCHEMBL1648507 | 0.73 | ROCK2 (1.00) | ROCK2ROCK1PRKACAPRKACGPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011050245-A1 | BICYCLIC HETEROARYLS AS KINASE INHIBITORS | FENG YANGBO (US) | 2011-04-28 | — | — | WO | disclosed |