Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 7/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | PRKDC | P78527 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38659181 | 0.84 | ALDH1A1 (0.71) | ERN1ALDH1A1CYP1A2CYP2C19PRKDC | |
| SCHEMBL295318 | 0.83 | ALDH1A1 (0.61) | ERN1ALDH1A1CYP1A2CYP2C19PRKDC | |
| SCHEMBL10322869 | 0.83 | ERN1 (0.51) | ERN1ALDH1A1CYP1A2CYP2C19PRKDC | |
| SCHEMBL1071145 | 0.82 | ERN1 (0.53) | ERN1ALDH1A1CYP1A2CYP2C19PRKDC | |
| SCHEMBL16475647 | 0.82 | ERN1 (0.68) | ERN1ALDH1A1CYP1A2CYP2C19PRKDC | |
| SCHEMBL30903836 | 0.82 | ERN1 (0.54) | ERN1ALDH1A1CYP1A2CYP2C19PRKDC | |
| SCHEMBL3152057 | 0.81 | PRKDC (0.58) | ERN1ALDH1A1CYP1A2CYP2C19PRKDC | |
| SCHEMBL22216903 | 0.81 | ERN1 (0.51) | ERN1ALDH1A1CYP1A2CYP2C19PRKDC | |
| SCHEMBL5883229 | 0.81 | ALDH1A1 (0.62) | ERN1ALDH1A1CYP1A2CYP2C19PRKDC | |
| SCHEMBL5882295 | 0.80 | ALDH1A1 (0.72) | ERN1ALDH1A1CYP1A2CYP2C19PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026102212-A1 | MACROCYCLIC MCL-1 INHIBITORS | VANDERBILT UNIVERSITY (US) | 2026-05-15 | — | — | WO | disclosed |
| US-12144816-B2 | Substituted indole Mcl-1 inhibitors | VANDERBILT UNIVERSITY (US) | 2024-11-19 | — | — | US | disclosed |
| EP-4292662-A2 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | Vanderbilt University (US) | 2023-12-20 | — | — | EP | disclosed |
| EP-3615514-B1 | PROPIONIC ACID DERIVATIVES AND METHODS OF USE THEREOF | AVIARA PHARMACEUTICALS INC (US) | 2023-11-22 | — | — | EP | disclosed |
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-10-19 | — | — | US | disclosed |
| EP-3423435-B1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | UNIV VANDERBILT (US) | 2023-08-23 | — | — | EP | disclosed |
| CN-110914242-B | Propionic acid derivatives and methods of use thereof | 阿维亚拉药品有限公司 | 2023-07-25 | — | — | CN | disclosed |
| US-11596639-B2 | Substituted indole Mcl-1 inhibitors | VANDERBILT UNIVERSITY (US) | 2023-03-07 | — | — | US | disclosed |
| CN-113666812-B | Synthesis method of 5-halogenated veratraldehyde | 四川大学 | 2022-06-24 | — | — | CN | disclosed |
| CN-109153643-B | Substituted indole MCL-1 inhibitors | 范德比尔特大学 | 2022-06-21 | — | — | CN | disclosed |
| US-5360582-A | Compositions with polymers for light sensitive elements | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1994-11-01 | — | — | US | disclosed |
| EP-0594697-A1 | NONLINEAR OPTICAL MATERIALS CONTAINING POLAR DISULFONE-FUNCTIONALIZED MOLECULES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1994-05-04 | — | — | EP | disclosed |
| WO-1993002383-A1 | NONLINEAR OPTICAL MATERIALS CONTAINING POLAR DISULFONE-FUNCTIONALIZED MOLECULES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1993-02-04 | — | — | WO | disclosed |
| US-5017569-A | Cephalosporin derivatives | ICI PHARMA (FR) | 1991-05-21 | — | — | US | disclosed |
| CN-87108011-A | New compounds with pharmacological activity, preparation method and related components thereof | ORION YHTYMAE OY (FI) | 1988-06-08 | — | — | CN | disclosed |
| US-4243783-A | Fluoroaliphaticsulfonyl substituted ethylenes catalysts in polymerization processes | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1981-01-06 | — | — | US | disclosed |
| US-4156696-A | Fluoroaliphaticsulfonyl substituted methanes | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1979-05-29 | — | — | US | disclosed |
| US-4069233-A | Fluoroaliphaticsulfonyl substituted ethylenes substituted by furyl, thenyl, or 1H-pyrrolyl groups | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1978-01-17 | — | — | US | disclosed |
| US-3984357-A | Fluoroaliphaticsulfonyl substituted ethylenes | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1976-10-05 | — | — | US | disclosed |
| US-3932526-A | Fluoroaliphaticsulfonyl substituted ethylenes | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1976-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12144816-B2 | Substituted indole Mcl-1 inhibitors | MCL1, BCL2L1, BCL9 | ERN1 1218/4885ALDH1A1 2556/4885CYP1A2 4125/4885 |
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | ERN1 1218/4885ALDH1A1 2556/4885CYP1A2 4125/4885 |
| US-11596639-B2 | Substituted indole Mcl-1 inhibitors | MCL1, BCL2L1, BCL9 | ERN1 1218/4885ALDH1A1 2556/4885CYP1A2 4125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.