Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12845955 | 0.84 | ROCK1 (0.56) | ALDH1A1GAAPOLBTSHRKDM4E | |
| SCHEMBL12846148 | 0.82 | ROCK1 (0.48) | ALDH1A1GAATSHRKDM4ESMN1; SMN2 | |
| SCHEMBL12846153 | 0.81 | NOS2 (0.57) | ALDH1A1KMT2AMEN1MAPTPOLB | |
| SCHEMBL1720663 | 0.80 | ALDH1A1 (0.47) | ALDH1A1KMT2AGAAMEN1MAPT | |
| SCHEMBL1720065 | 0.80 | PARP1 (0.71) | ALDH1A1KMT2AGAAMEN1MAPT | |
| SCHEMBL12846182 | 0.78 | NOS2 (0.53) | ALDH1A1KMT2AMEN1MAPTPOLB | |
| SCHEMBL12846181 | 0.78 | ALDH1A1 (0.52) | ALDH1A1KMT2APOLBTSHRKDM4E | |
| SCHEMBL12846152 | 0.77 | ALDH1A1 (0.54) | ALDH1A1KMT2AMEN1MAPTPOLB | |
| SCHEMBL1789261 | 0.76 | ATM (0.50) | ALDH1A1GAAMAPTPOLBKDM4E | |
| SCHEMBL19902592 | 0.76 | ATM (0.44) | ALDH1A1KMT2APOLBKDM4EPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150072972-A1 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-03-12 | — | — | US | disclosed |
| US-20150072972-A1 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-03-12 | — | — | US | disclosed |
| US-8946221-B2 | Phthalazine derivatives as PARP inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2015-02-03 | — | — | US | disclosed |
| US-8946221-B2 | Phthalazine derivatives as PARP inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2015-02-03 | — | — | US | disclosed |
| US-20110065684-A1 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS | MEVELLEC LAURENCE ANNE | 2011-03-17 | — | — | US | disclosed |
| US-20110065684-A1 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS | MEVELLEC LAURENCE ANNE | 2011-03-17 | — | — | US | disclosed |
| US-7803795-B2 | Phthalazine derivatives as parp inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-09-28 | — | — | US | disclosed |
| US-7803795-B2 | Phthalazine derivatives as parp inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-09-28 | — | — | US | disclosed |
| US-20080139568-A1 | Phthalazine Derivatives as Parp Inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-06-12 | — | — | US | disclosed |
| US-20080139568-A1 | Phthalazine Derivatives as Parp Inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150072972-A1 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS | PARP1, PARP2, PARP11 | ALDH1A1 551/4885KMT2A 129/4885GAA 3119/4885 |
| US-20080139568-A1 | Phthalazine Derivatives as Parp Inhibitors | PARP1, PARP2, PARP11 | ALDH1A1 494/4885KMT2A 131/4885GAA 3085/4885 |
| US-20110065684-A1 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS | PARP1, PARP2, PARP11 | ALDH1A1 551/4885KMT2A 129/4885GAA 3119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.