Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 7/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1663095 | 0.83 | P2RX7 (0.37) | PARP1PARP2P2RX7RAB9APOLB | |
| SCHEMBL12795027 | 0.83 | HSP90AA1 (0.38) | HSP90AA1MDM2JAK2RORCPDE10A | |
| SCHEMBL1663113 | 0.81 | SMURF2 (0.34) | RORC | |
| SCHEMBL12797134 | 0.79 | HSP90AA1 (0.41) | HSP90AA1MDM2RORCPDE10APARP1 | |
| SCHEMBL1663267 | 0.71 | P2RX7 (0.39) | PARP1PARP2P2RX7RAB9APOLB | |
| SCHEMBL1663216 | 0.69 | P2RX7 (0.40) | PARP1PARP2P2RX7GAANTRK1 | |
| SCHEMBL12794883 | 0.67 | HSP90AA1 (0.40) | HSP90AA1MDM2RORCPARP1GAA | |
| SCHEMBL12796778 | 0.67 | P2RX7 (0.35) | PARP1PARP2P2RX7NTRK1 | |
| SCHEMBL1663246 | 0.67 | P2RX7 (0.35) | PARP1PARP2P2RX7RAB9APOLB | |
| SCHEMBL1662776 | 0.67 | PIK3CA (0.34) | PARP1PARP2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011050284-A1 | PYRAZOLYLPYRIDINE ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2011-04-28 | — | — | WO | disclosed |