Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 5/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12796038 | 0.85 | HSP90AA1 (0.40) | HSP90AA1POLBTDP1USP2ALDH1A1 | |
| SCHEMBL12797134 | 0.84 | HSP90AA1 (0.41) | HSP90AA1POLBTDP1USP2ALDH1A1 | |
| SCHEMBL12794882 | 0.83 | HSP90AA1 (0.37) | HSP90AA1POLBTDP1USP2ALDH1A1 | |
| SCHEMBL1663741 | 0.78 | P2RX7 (0.42) | USP2ALDH1A1GAACASP1CASP7 | |
| SCHEMBL1665603 | 0.77 | MAPT (0.45) | POLBUSP2ALDH1A1GAACASP1 | |
| SCHEMBL1663326 | 0.74 | ALDH1A1 (0.41) | POLBALDH1A1GAACASP1CASP7 | |
| SCHEMBL1662991 | 0.68 | P2RX7 (0.39) | USP2ALDH1A1GAACASP1CASP7 | |
| SCHEMBL12796922 | 0.67 | HSP90AA1 (0.38) | HSP90AA1POLBTDP1GAARORC | |
| SCHEMBL9971920 | 0.67 | HSD11B1 (0.53) | HSP90AA1POLBTDP1GAAMAPK14 | |
| SCHEMBL12795937 | 0.67 | P2RX7 (0.39) | USP2ALDH1A1GAACASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011050284-A1 | PYRAZOLYLPYRIDINE ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2011-04-28 | — | — | WO | disclosed |