⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16108499 | 1.00 | SMN1; SMN2 (0.43) | — | |
| SCHEMBL9645379 | 0.93 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL9645375 | 0.93 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL9645385 | 0.93 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL14039649 | 0.91 | SMN1; SMN2 (0.38) | — | |
| SCHEMBL128700 | 0.90 | — | — | |
| SCHEMBL12064423 | 0.90 | CYP1A2 (0.41) | — | |
| SCHEMBL17592647 | 0.89 | NCF1 (0.37) | — | |
| SCHEMBL17592191 | 0.89 | NCF1 (0.37) | — | |
| SCHEMBL13500013 | 0.89 | TSHR (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230331691-A1 | TREPROSTINIL DERIVATIVE COMPOUNDS AND METHODS OF USING SAME | Corsair Pharma, Inc. | 2023-10-19 | — | — | US | disclosed |
| US-9845305-B2 | Treprostinil derivative compounds and methods of using same | Corsair Pharma, Inc. (US) | 2017-12-19 | — | — | US | disclosed |
| US-20170081303-A1 | TREPROSTINIL DERIVATIVE COMPOUNDS AND METHODS OF USING SAME | Corsair Pharma, Inc. | 2017-03-23 | — | — | US | disclosed |
| US-9505737-B2 | Treprostinil derivative compounds and methods of using same | Corsair Pharma, Inc. (US) | 2016-11-29 | — | — | US | disclosed |
| EP-2978752-A1 | 6-(5-HYDROXY-1H-PYRAZOL-1-YL)NICOTINAMIDE DERIVATIVES AND THEIR USE AS PHD INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2016-02-03 | — | — | EP | disclosed |
| US-9198432-B2 | 1,2,4-triazolyl-substituted ketoenols | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-12-01 | — | — | US | disclosed |
| US-20150166503-A1 | TREPROSTINIL DERIVATIVE COMPOUNDS AND METHODS OF USING SAME | Corsair Pharma, Inc. | 2015-06-18 | — | — | US | disclosed |
| US-9006307-B2 | Direct to-metal and exterior durable non-skid coating | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2015-04-14 | — | — | US | disclosed |
| US-9000189-B2 | Biphenyl-substituted spirocyclic ketoenols | BAYER CROPSCIENCE AG (DE) | 2015-04-07 | — | — | US | disclosed |
| US-8901038-B2 | Biphenyl-substituted cyclic ketoenols | BAYER CROPSCIENCE AG (DE) | 2014-12-02 | — | — | US | disclosed |
| EP-1047693-A1 | HERBICIDES 3-(BENZAZOL-4-YL)PYRIMIDINE-DIONE-DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-02 | — | — | EP | disclosed |
| EP-0998472-A1 | SUBSTITUTED 2-(BENZOARYL)PYRIDINES | BASF AKTIENGESELLSCHAFT (DE) | 2000-05-10 | — | — | EP | disclosed |
| CN-1244865-A | Substituted pyrazole-3-yl benzazoles | BASF AK (DE) | 2000-02-16 | — | — | CN | disclosed |
| WO-1999055702-A1 | SUBSTITUTED (4-BROMPYRAZOLE-3-YL)BENZAZOLES | BASF AKTIENGESELLSCHAFT (DE) | 1999-11-04 | — | — | WO | disclosed |
| EP-0944623-A2 | SUBSTITUTED PYRAZOLE-3-YL BENZAZOLES | BASF AKTIENGESELLSCHAFT (DE) | 1999-09-29 | — | — | EP | disclosed |
| WO-1999031091-A1 | HERBICIDES 3-(BENZAZOL-4-YL)PYRIMIDINE-DIONE-DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 1999-06-24 | — | — | WO | disclosed |
| EP-0915853-A1 | SUBSTITUTED 3-PHENYL PYRAZOLES | BASF AKTIENGESELLSCHAFT (DE) | 1999-05-19 | — | — | EP | disclosed |
| WO-1999006394-A1 | SUBSTITUTED 2-(BENZOARYL)PYRIDINES | BASF AKTIENGESELLSCHAFT (DE) | 1999-02-11 | — | — | WO | disclosed |
| WO-1998027090-A2 | SUBSTITUTED PYRAZOLE-3-YL BENZAZOLES | BASF AKTIENGESELLSCHAFT (DE) | 1998-06-25 | — | — | WO | disclosed |
| WO-1998005649-A1 | SUBSTITUTED 3-PHENYL PYRAZOLES | BASF AKTIENGESELLSCHAFT (DE) | 1998-02-12 | — | — | WO | disclosed |