Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.71 |
| ▸ | PLK1 | P53350 | 2/20 | 0.61 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.60 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | BCR | P11274 | 2/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 1/20 | 0.56 |
| ▸ | PRKACG | P22612 | 1/20 | 0.56 |
| ▸ | PRKACB | P22694 | 1/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.54 |
| ▸ | JAK2 | O60674 | 3/20 | 0.53 |
| ▸ | SYK | P43405 | 2/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12273795 | 0.84 | SYK (0.54) | CDK5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL4901211 | 0.83 | CDK5 (0.75) | CDK5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL6976454 | 0.83 | ZAP70 (0.71) | CDK5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL12801118 | 0.82 | CDK5 (0.73) | CDK5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL2939794 | 0.82 | CDK5 (0.80) | CDK5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL4737495 | 0.81 | PLK1 (0.77) | CDK5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL12274339 | 0.81 | PIK3CG (0.60) | CDK5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL823915 | 0.81 | CAMK2D (0.82) | CDK5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL12801643 | 0.81 | CDK5 (0.82) | CDK5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL12801287 | 0.80 | PLK1 (0.82) | CDK5MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |