Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 4/20 | 0.77 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | NPC1 | O15118 | 2/20 | 0.72 |
| ▸ | RAB9A | P51151 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.72 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.67 |
| ▸ | JAK2 | O60674 | 1/20 | 0.65 |
| ▸ | ABL1 | P00519 | 3/20 | 0.62 |
| ▸ | BCR | P11274 | 3/20 | 0.62 |
| ▸ | SRC | P12931 | 2/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | PRKACA | P17612 | 1/20 | 0.62 |
| ▸ | PRKACG | P22612 | 1/20 | 0.62 |
| ▸ | PRKACB | P22694 | 1/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.56 |
| ▸ | SYK | P43405 | 2/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801287 | 0.91 | PLK1 (0.82) | PLK1CDK5MEN1NPC1RAB9A | |
| SCHEMBL27444270 | 0.88 | PLK1 (0.78) | PLK1CDK5MEN1NPC1RAB9A | |
| SCHEMBL4907230 | 0.87 | PLK1 (1.00) | PLK1CDK5MEN1NPC1RAB9A | |
| SCHEMBL27446266 | 0.87 | PLK1 (0.77) | PLK1CDK5MEN1NPC1RAB9A | |
| SCHEMBL823915 | 0.86 | CAMK2D (0.82) | PLK1CDK5MEN1NPC1RAB9A | |
| SCHEMBL25337631 | 0.86 | PLK1 (0.72) | PLK1CDK5MEN1NPC1RAB9A | |
| SCHEMBL30554478 | 0.86 | PLK1 (0.72) | PLK1CDK5MEN1NPC1RAB9A | |
| SCHEMBL12801281 | 0.84 | PLK1 (0.72) | PLK1CDK5MEN1NPC1RAB9A | |
| SCHEMBL31119008 | 0.83 | PLK1 (0.74) | PLK1CDK5MEN1NPC1RAB9A | |
| SCHEMBL25337710 | 0.83 | PLK1 (0.74) | PLK1CDK5MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080153822-A1 | Methods of treating pain | INGENIUM PHARMACEUTICALS GMBH (DE) | 2008-06-26 | — | — | US | claimed |
| WO-2008065155-A1 | CDK INHIBITORS FOR TREATING PAIN | INGENIUM PHARMACEUTICALS GMBH (DE) | 2008-06-05 | — | — | WO | claimed |
| US-20070021419-A1 | 2-Aminophenyl-4-phenylpyrimidines as kinase inhibitors | CYCLACEL LIMITED (GB) | 2007-01-25 | — | — | US | claimed |
| US-20070021419-A1 | 2-Aminophenyl-4-phenylpyrimidines as kinase inhibitors | CYCLACEL LIMITED (GB) | 2007-01-25 | — | — | US | disclosed |
| US-20070021419-A1 | 2-Aminophenyl-4-phenylpyrimidines as kinase inhibitors | CYCLACEL LIMITED (GB) | 2007-01-25 | — | — | US | disclosed |
| US-20070021419-A1 | 2-Aminophenyl-4-phenylpyrimidines as kinase inhibitors | CYCLACEL LIMITED (GB) | 2007-01-25 | — | — | US | disclosed |
| EP-1648875-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | Cyclacel Limited (GB) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005012262-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |
| WO-2005012262-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021419-A1 | 2-Aminophenyl-4-phenylpyrimidines as kinase inhibitors | GRK3, NCOR1, GRM3 | PLK1 1603/4885CDK5 737/4885MEN1 3759/4885 |
| US-20080153822-A1 | Methods of treating pain | OPRL1, ACHE, OPRK1 | PLK1 3544/4885CDK5 2587/4885MEN1 3807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.