Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.37 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.37 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.37 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.37 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.37 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1667558 | 0.85 | TBK1 (0.48) | SYKTBK1IKBKE | |
| SCHEMBL12801501 | 0.81 | KMO (0.47) | PIK3CATBK1IKBKE | |
| SCHEMBL12800881 | 0.79 | PDE4B (0.46) | PIK3CACACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL12801121 | 0.74 | JAK2 (0.49) | JAK2TBK1IKBKE | |
| SCHEMBL12801073 | 0.72 | JAK2 (0.69) | SYKJAK2LRRK2TBK1IKBKE | |
| SCHEMBL12801634 | 0.72 | KMO (0.50) | PIK3CAJAK2ALDH1A1EGFRCDK2 | |
| SCHEMBL12801199 | 0.71 | KMT2A (0.40) | SYKPIK3CACACNB4CACNA1ACACNA1G | |
| SCHEMBL12801197 | 0.71 | PDE4D (0.38) | SYKPIK3CACACNB4CACNA1ACACNA1G | |
| SCHEMBL1667272 | 0.70 | TBK1 (0.64) | TBK1IKBKE | |
| SCHEMBL24904207 | 0.70 | IKBKE (0.46) | SYKPIK3CATBK1IKBKECDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |