Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.39 |
| ▸ | PDE4A | P27815 | 5/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25114861 | 0.88 | NPY1R (0.42) | NPY1RNPY2RSLC6A4HTR6CSNK2A1 | |
| SCHEMBL1136135 | 0.85 | NPY1R (0.50) | PDE4DPDE4APDE4BPDE4CNPY1R | |
| SCHEMBL19527744 | 0.83 | SYK (0.47) | SYKPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL739389 | 0.81 | SYK (0.48) | SYKPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2834716 | 0.81 | SYK (0.48) | SYKPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1613268 | 0.81 | SYK (0.44) | SYKPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL19175446 | 0.81 | SYK (0.44) | SYKPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL12126088 | 0.80 | SYK (0.42) | SYKPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL14862649 | 0.78 | FPR2 (0.43) | NPY1RNPY2R | |
| SCHEMBL21191007 | 0.77 | SYK (0.44) | SYKPDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012142329-A1 | COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS | MYREXIS, INC. (US) | 2012-10-18 | — | — | WO | disclosed |
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |