Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 13/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.51 |
| ▸ | PRKCG | P05129 | 4/20 | 0.51 |
| ▸ | PRKCB | P05771 | 4/20 | 0.51 |
| ▸ | LCK | P06239 | 4/20 | 0.51 |
| ▸ | PRKCA | P17252 | 4/20 | 0.51 |
| ▸ | PRKCH | P24723 | 4/20 | 0.51 |
| ▸ | PRKCI | P41743 | 4/20 | 0.51 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.51 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.51 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1667770 | 0.88 | TBK1 (0.56) | ZAP70JAK2 | |
| SCHEMBL12801104 | 0.83 | JAK2 (0.47) | ZAP70PRKD3PRKCGPRKCBLCK | |
| SCHEMBL12800915 | 0.83 | JAK2 (0.62) | JAK2 | |
| SCHEMBL12801368 | 0.83 | GSK3B (0.43) | ZAP70JAK2CDK2IKBKBIGF1R | |
| SCHEMBL12522369 | 0.82 | SYK (0.40) | EGFRJAK2CDK2IKBKBCHUK | |
| SCHEMBL12801107 | 0.80 | TBK1 (0.47) | JAK2CDK2PIK3CGIKBKBCHUK | |
| SCHEMBL1667112 | 0.80 | TBK1 (0.53) | JAK2 | |
| SCHEMBL12522198 | 0.79 | TBK1 (0.52) | JAK2SYK | |
| SCHEMBL12521964 | 0.79 | CCNC (0.47) | ZAP70JAK2CDK2IKBKBIGF1R | |
| SCHEMBL12801550 | 0.79 | JAK2 (0.60) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |