Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.57 |
| ▸ | JAK3 | P52333 | 9/20 | 0.53 |
| ▸ | JAK1 | P23458 | 4/20 | 0.52 |
| ▸ | TYK2 | P29597 | 4/20 | 0.52 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.50 |
| ▸ | FLT3 | P36888 | 2/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801550 | 0.92 | JAK2 (0.60) | JAK2JAK3JAK1TYK2TBK1 | |
| SCHEMBL12801176 | 0.90 | JAK2 (0.64) | JAK2JAK3JAK1TYK2TBK1 | |
| SCHEMBL12801563 | 0.89 | JAK2 (0.57) | JAK2JAK3JAK1TYK2TBK1 | |
| SCHEMBL12801574 | 0.89 | JAK2 (0.55) | JAK2JAK3JAK1TYK2TBK1 | |
| SCHEMBL12801254 | 0.89 | JAK2 (0.57) | JAK2JAK3JAK1TYK2TBK1 | |
| SCHEMBL12522351 | 0.89 | TBK1 (0.66) | JAK2TBK1IKBKE | |
| SCHEMBL12800915 | 0.89 | JAK2 (0.62) | JAK2JAK3JAK1TYK2TBK1 | |
| SCHEMBL12801555 | 0.88 | JAK2 (0.59) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL12800908 | 0.88 | JAK2 (0.63) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL12800922 | 0.87 | JAK2 (0.58) | JAK2JAK3JAK1TYK2TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |