Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 14/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 9/20 | 0.57 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | CD63 | P08962 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801627 | 0.88 | MAPT (0.56) | MAPTLMNAMAPK1ABCG2ABCB1 | |
| SCHEMBL1667296 | 0.84 | ABCG2 (0.60) | MAPTLMNAMAPK1ABCG2ABCB1 | |
| SCHEMBL12275273 | 0.81 | MAPT (0.53) | MAPTLMNAMAPK1ABCG2ABCB1 | |
| SCHEMBL12274278 | 0.80 | MAPT (0.60) | MAPTLMNAMAPK1ABCG2ABCB1 | |
| SCHEMBL12801657 | 0.79 | SYK (0.51) | MEN1KMT2AFLT3CD63SYK | |
| SCHEMBL12801284 | 0.78 | PAK1 (0.53) | MEN1KMT2AFLT3CD63SYK | |
| SCHEMBL8899168 | 0.78 | ABCG2 (0.72) | MAPTLMNAABCG2ABCB1ABCC1 | |
| Hydrochloric Acid SCHEMBL8907536 | 0.77 | ABCG2 (0.70) | MAPTLMNAABCG2ABCB1ABCC1 | |
| SCHEMBL12801614 | 0.76 | SYK (0.55) | MAPTABCG2ABCB1ABCC1MEN1 | |
| SCHEMBL369450 | 0.75 | PDE4A (0.59) | MAPTABCG2MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |