Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.59 |
| ▸ | WHR1 | P49842 | 1/20 | 0.50 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | KRAS | P01116 | 1/20 | 0.45 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1940967 | 0.89 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DWHR1 | |
| SCHEMBL12621367 | 0.88 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DWHR1 | |
| SCHEMBL16502036 | 0.86 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DWHR1 | |
| SCHEMBL1941945 | 0.86 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DWHR1 | |
| SCHEMBL1942476 | 0.86 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DWHR1 | |
| SCHEMBL22144635 | 0.85 | WHR1 (0.68) | PDE4APDE4BPDE4CPDE4DWHR1 | |
| SCHEMBL1940456 | 0.85 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DWHR1 | |
| SCHEMBL1940193 | 0.84 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DWHR1 | |
| SCHEMBL295421 | 0.82 | WHR1 (0.52) | PDE4APDE4DWHR1MAPTKRAS | |
| SCHEMBL1943621 | 0.82 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DWHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101687820-B | Process for producing quinazoline derivative | EISAI R&D MAN CO LTD | 2012-07-25 | — | — | CN | claimed |
| CN-102532041-A | Process for producing quinazoline derivative | EISAI R&D MAN CO LTD | 2012-07-04 | — | — | CN | claimed |
| CN-101687820-A | Process for producing quinazoline derivative | EISAI R&D MAN CO LTD | 2010-03-31 | — | — | CN | claimed |
| US-10357495-B2 | Topical formulations of PDE-4 inhibitors and their methods of use | Dermavant Sciences GmbH (CH) | 2019-07-23 | — | — | US | disclosed |
| US-20190134036-A1 | TOPICAL FORMULATIONS OF PDE-4 INHIBITORS AND THEIR METHODS OF USE | Dermavant Sciences GmbH (CH) | 2019-05-09 | — | — | US | disclosed |
| US-10206925-B2 | Topical formulations of PDE-4 inhibitors and their methods of use | EISAI R&D MANAGEMENT CO, LTD. (JP) | 2019-02-19 | — | — | US | disclosed |
| WO-2017214289-A1 | TOPICAL FORMULATIONS OF PDE-4 INHIBITORS AND THEIR METHODS OF USE | Dermavant Sciences GmbH (CH) | 2017-12-14 | — | — | WO | disclosed |
| US-20170348311-A1 | TOPICAL FORMULATIONS OF PDE-4 INHIBITORS AND THEIR METHODS OF USE | Dermavant Sciences GmbH (CH) | 2017-12-07 | — | — | US | disclosed |
| CN-102336717-B | Quinazoline derivatives | EISAI R&D MAN CO LTD | 2013-09-18 | — | — | CN | disclosed |
| US-8530654-B2 | Crystals, amorphous substances or salts of methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl) phenyl] terephthalamic acid | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-09-10 | — | — | US | disclosed |
| US-8530654-B2 | Crystals, amorphous substances or salts of methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl) phenyl] terephthalamic acid | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-09-10 | — | — | US | disclosed |
| US-20090062539-A1 | CRYSTALS, AMORPHOUS SUBSTANCES OR SALTS OF METHYL N-[3-(6,7-DIMETHOXY-2-METHYLAMINOQUINAZOLIN-4-YL) PHENYL] TEREPHTHALAMIC ACID | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-03-05 | — | — | US | disclosed |
| US-20090062539-A1 | CRYSTALS, AMORPHOUS SUBSTANCES OR SALTS OF METHYL N-[3-(6,7-DIMETHOXY-2-METHYLAMINOQUINAZOLIN-4-YL) PHENYL] TEREPHTHALAMIC ACID | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-03-05 | — | — | US | disclosed |
| EP-1992622-A1 | 4-(3-BENZOYLAMINOPHENYL)-6,7-DIMETHOXY-2- METHYLAMINOQUINAZOLINE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2008-11-19 | — | — | EP | disclosed |
| US-20070299094-A1 | 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives | EISAI R&D MANAGEMENT CO., LTD. | 2007-12-27 | — | — | US | disclosed |
| US-20070299094-A1 | 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives | EISAI R&D MANAGEMENT CO., LTD. | 2007-12-27 | — | — | US | disclosed |
| US-6800644-B2 | PHOSPHODIESTERASE-4 INHIBITOR, AMINOQUINOLINE OR AMINOISOQUINOLINE DERIVATIVES | EISAI CO., LTD. (JP) | 2004-10-05 | — | — | US | disclosed |
| US-20020055516-A1 | Nitrogen-containing heterocyclic compounds and medicaments containing the compounds | EISAI CO., LTD. | 2002-05-09 | — | — | US | disclosed |
| US-6352989-B1 | ENZYME INHIBITORS FOR PHOSPHODIESTERASE | EISAI CO., LTD. (JP) | 2002-03-05 | — | — | US | disclosed |
| EP-1052254-A1 | NITROGENOUS HETEROCYCLIC DERIVATIVES AND MEDICINE THEREOF | Eisai Co., Ltd. (JP) | 2000-11-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020055516-A1 | Nitrogen-containing heterocyclic compounds and medicaments containing the compounds | PDE4A, PDE4B, PDE5A | PDE4A 1/4885PDE4B 2/4885PDE4C 7/4885 |
| US-10206925-B2 | Topical formulations of PDE-4 inhibitors and their methods of use | PDE4A, PDE4B, PDE4C | PDE4A 1/4885PDE4B 2/4885PDE4C 3/4885 |
| US-20070299094-A1 | 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives | ITCH, HRH4, HRH1 | PDE4A 1280/4885PDE4B 1378/4885PDE4C 2057/4885 |
| US-20170348311-A1 | TOPICAL FORMULATIONS OF PDE-4 INHIBITORS AND THEIR METHODS OF USE | PDE4A, PDE4B, PDE4C | PDE4A 1/4885PDE4B 2/4885PDE4C 3/4885 |
| US-10357495-B2 | Topical formulations of PDE-4 inhibitors and their methods of use | PDE4A, PDE4B, PDE4C | PDE4A 1/4885PDE4B 2/4885PDE4C 3/4885 |
| US-20090062539-A1 | CRYSTALS, AMORPHOUS SUBSTANCES OR SALTS OF METHYL N-[3-(6,7-DIMETHOXY-2-METHYLAMINOQUINAZOLIN-4-YL) PHENYL] TEREPHTHALAMIC ACID | PDE4A, PDE4B, PDE7A | PDE4A 1/4885PDE4B 2/4885PDE4C 5/4885 |
| US-20190134036-A1 | TOPICAL FORMULATIONS OF PDE-4 INHIBITORS AND THEIR METHODS OF USE | PDE4A, PDE4B, PDE4C | PDE4A 1/4885PDE4B 2/4885PDE4C 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.