Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 13/20 | 0.51 |
| ▸ | TBK1 | Q9UHD2 | 13/20 | 0.51 |
| ▸ | ABL1 | P00519 | 3/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | PRKCA | P17252 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 4/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | BCR | P11274 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12800945 | 0.92 | IKBKE (0.51) | IKBKETBK1ABL1PDGFRBPDGFRA | |
| SCHEMBL12800407 | 0.90 | IKBKE (0.51) | IKBKETBK1ABL1PDGFRBPDGFRA | |
| SCHEMBL1667609 | 0.89 | TBK1 (0.65) | IKBKETBK1 | |
| SCHEMBL12801719 | 0.88 | JAK2 (0.55) | IKBKETBK1JAK2HDAC1HDAC6 | |
| SCHEMBL12801132 | 0.86 | IKBKE (0.52) | IKBKETBK1ABL1PDGFRBPDGFRA | |
| SCHEMBL12800938 | 0.85 | TBK1 (0.51) | IKBKETBK1ABL1PDGFRBPDGFRA | |
| SCHEMBL12801721 | 0.85 | IKBKE (0.51) | IKBKETBK1ABL1PDGFRBPDGFRA | |
| SCHEMBL12801371 | 0.84 | IKBKE (0.49) | IKBKETBK1JAK2JAK3 | |
| SCHEMBL12801175 | 0.84 | IKBKE (0.50) | IKBKETBK1ABL1PDGFRBPDGFRA | |
| SCHEMBL12800943 | 0.84 | IKBKE (0.51) | IKBKETBK1JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |