Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.55 |
| ▸ | IKBKE | Q14164 | 8/20 | 0.54 |
| ▸ | TBK1 | Q9UHD2 | 8/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801132 | 0.91 | IKBKE (0.52) | JAK2IKBKETBK1 | |
| SCHEMBL12801721 | 0.90 | IKBKE (0.51) | JAK2IKBKETBK1JAK3 | |
| SCHEMBL12800938 | 0.90 | TBK1 (0.51) | JAK2IKBKETBK1 | |
| SCHEMBL12800945 | 0.90 | IKBKE (0.51) | JAK2IKBKETBK1JAK3 | |
| SCHEMBL12800943 | 0.89 | IKBKE (0.51) | JAK2IKBKETBK1JAK3 | |
| SCHEMBL12801648 | 0.88 | IKBKE (0.51) | JAK2IKBKETBK1JAK3HDAC1 | |
| SCHEMBL1667605 | 0.88 | IKBKE (0.68) | IKBKETBK1 | |
| SCHEMBL12801583 | 0.88 | IKBKE (0.56) | JAK2IKBKETBK1 | |
| SCHEMBL12801371 | 0.88 | IKBKE (0.49) | JAK2IKBKETBK1JAK3 | |
| SCHEMBL12801140 | 0.87 | IKBKE (0.50) | JAK2IKBKETBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |