Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.51 |
| ▸ | MTOR | P42345 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14254278 | 0.85 | SRC (0.55) | PLK1JAK2FLT3CAMK2DCDK5 | |
| SCHEMBL14253998 | 0.84 | MTOR (0.52) | PLK1MTORJAK2FLT3CAMK2D | |
| SCHEMBL14254202 | 0.84 | JAK2 (0.53) | KDM4EGAAL3MBTL1JAK2FLT3 | |
| SCHEMBL12800930 | 0.83 | PLK1 (0.51) | PLK1JAK2FLT3CAMK2DCLK1 | |
| SCHEMBL12801101 | 0.83 | JAK2 (0.58) | PLK1JAK2FLT3CDK5MEN1 | |
| SCHEMBL14254230 | 0.83 | CAMK2D (0.59) | PLK1JAK2FLT3CAMK2DPIK3CG | |
| SCHEMBL14254276 | 0.81 | PIK3CA (0.51) | PLK1MTORJAK2FLT3MEN1 | |
| SCHEMBL14254277 | 0.80 | CAMK2D (0.71) | PLK1MTORJAK2FLT3CAMK2D | |
| SCHEMBL12801690 | 0.80 | PIK3CG (0.54) | PLK1JAK2FLT3CAMK2DCDK5 | |
| SCHEMBL14254228 | 0.80 | PIK3CG (0.71) | PLK1MTORJAK2FLT3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |