Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 3/20 | 0.51 |
| ▸ | IKBKB | O14920 | 3/20 | 0.50 |
| ▸ | CHUK | O15111 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 7/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.47 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | DKK1 | O94907 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801690 | 0.85 | PIK3CG (0.54) | PLK1GSK3BCDK2CAMK2DJAK2 | |
| SCHEMBL27116134 | 0.84 | GSK3B (0.52) | PLK1IKBKBCHUKGSK3BCDK2 | |
| SCHEMBL12801692 | 0.83 | PLK1 (0.51) | PLK1IKBKBGSK3BCDK2CAMK2D | |
| SCHEMBL14254230 | 0.83 | CAMK2D (0.59) | PLK1IKBKBGSK3BCAMK2DJAK2 | |
| SCHEMBL14254277 | 0.82 | CAMK2D (0.71) | PLK1CDK2CAMK2DJAK2FLT3 | |
| SCHEMBL14254278 | 0.81 | SRC (0.55) | PLK1IKBKBGSK3BCDK2CAMK2D | |
| SCHEMBL12801101 | 0.81 | JAK2 (0.58) | PLK1IKBKBGSK3BCDK2JAK2 | |
| SCHEMBL16941489 | 0.78 | ABL1 (0.61) | PLK1IKBKBCHUKGSK3BCDK2 | |
| SCHEMBL14254228 | 0.77 | PIK3CG (0.71) | PLK1IKBKBGSK3BCDK2DYRK1A | |
| SCHEMBL12801126 | 0.77 | JAK2 (0.52) | PLK1GSK3BCAMK2DJAK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |