Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 8/20 | 0.45 |
| ▸ | CDK1 | P06493 | 7/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 9/20 | 0.43 |
| ▸ | JAK1 | P23458 | 8/20 | 0.43 |
| ▸ | JAK3 | P52333 | 6/20 | 0.43 |
| ▸ | TYK2 | P29597 | 5/20 | 0.43 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12802007 | 0.85 | EIF2AK4 (0.53) | EIF2AK4AURKACDK1CCNB1ALK | |
| SCHEMBL1662621 | 0.85 | EIF2AK4 (0.52) | EIF2AK4AURKACDK1CCNB1ALK | |
| SCHEMBL1356818 | 0.83 | EIF2AK4 (0.58) | EIF2AK4AURKACDK1CCNB1FLT3 | |
| SCHEMBL12801913 | 0.82 | CDK9 (0.53) | EIF2AK4CDK1CCNB1ALKJAK2 | |
| SCHEMBL12797028 | 0.82 | EIF2AK4 (0.51) | EIF2AK4AURKACDK1CCNB1ALK | |
| SCHEMBL12797314 | 0.81 | EIF2AK4 (0.56) | EIF2AK4AURKAALKJAK2JAK1 | |
| SCHEMBL12796009 | 0.81 | EIF2AK4 (0.56) | EIF2AK4ALKJAK2JAK1JAK3 | |
| SCHEMBL2585171 | 0.81 | EIF2AK4 (0.55) | EIF2AK4ALKJAK2JAK1JAK3 | |
| SCHEMBL12797147 | 0.78 | JAK2 (0.52) | EIF2AK4AURKACDK1ALKJAK2 | |
| SCHEMBL12797120 | 0.78 | EIF2AK4 (0.51) | EIF2AK4CDK1ALKJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242987-B2 | Heterocyclyl pyrazolopyrimidine analogues as JAK inhibitors | CELLZOME LIMITED (GB) | 2016-01-26 | — | — | US | claimed |
| US-20120252779-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2012-10-04 | — | — | US | claimed |
| US-9242987-B2 | Heterocyclyl pyrazolopyrimidine analogues as JAK inhibitors | CELLZOME LIMITED (GB) | 2016-01-26 | — | — | US | disclosed |
| US-9242987-B2 | Heterocyclyl pyrazolopyrimidine analogues as JAK inhibitors | CELLZOME LIMITED (GB) | 2016-01-26 | — | — | US | disclosed |
| US-9242987-B2 | Heterocyclyl pyrazolopyrimidine analogues as JAK inhibitors | CELLZOME LIMITED (GB) | 2016-01-26 | — | — | US | disclosed |
| US-20120252779-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2012-10-04 | — | — | US | disclosed |
| US-20120252779-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2012-10-04 | — | — | US | disclosed |
| US-20120252779-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2012-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252779-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | JAK1, JAK3, JAK2 | EIF2AK4 1347/4885AURKA 965/4885CDK1 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.