SCHEMBL128037

SCHEMBL128037

Nc1nc(N)nc(N2CC2)n1

nearest known ligand 0.68

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 15/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10453209 1.00 HRH4 (0.59) HRH4
SCHEMBL11150401 0.94 HRH4 (0.59) HRH4
SCHEMBL21325614 0.89 ALDH1A1 (0.51) HRH4
SCHEMBL3027569 0.89 HRH4 (0.50) HRH4
SCHEMBL5032275 0.88 HRH4 (0.78) HRH4
Hydrochloric Acid SCHEMBL31046080 0.87 ALDH1A1 (0.50) HRH4
SCHEMBL5033361 0.87 ALDH1A1 (0.54) HRH4
SCHEMBL4445737 0.87 ALDH1A1 (0.54) HRH4
SCHEMBL8962532 0.83 HRH1 (0.61) HRH4
SCHEMBL4445432 0.83 HRH4 (0.46) HRH4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4243874-A1 MACROPINOCYTOSIS SELECTIVE MONOBODY-DRUG CONJUGATES New York University (US) 2023-09-20 EP claimed
WO-2022103856-A1 MACROPINOCYTOSIS SELECTIVE MONOBODY-DRUG CONJUGATES NEW YORK UNIVERSITY (US) 2022-05-19 WO claimed
EP-3377043-A1 DEFORMABLE NANO-SCALE VEHICLES (DNVS) FOR TRANS-BLOOD BRAIN BARRIER, TRANS-MUCOSAL, AND TRANSDERMAL DRUG DELIVERY The Regents of The University of California (US) 2018-09-26 EP claimed
CN-1816564-B Rasgap derived peptide for selectively killing cancer cells UNIV LAUSANNE 2010-11-24 CN claimed
CN-100415827-C Fire resistance polyester film and processed product using the film TORAY INDUSTRIES (JP) 2008-09-03 CN claimed
JP-58153785-A None JP disclosed
EP-4392056-A2 ENDOSTATIN PEPTIDES FOR THE TREATMENT OF TUMORS, FIBROSIS AND ACUTE LUNG INJURY Musc Foundation for Research Development (US) 2024-07-03 EP disclosed
WO-2024076964-A1 PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF THOMAS JEFFERSON UNIVERSITY (US) 2024-04-11 WO disclosed
WO-2023196957-A2 BISPECIFIC T CELL ENGAGERS TARGETING TUMOR ANTIGENS THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) 2023-10-12 WO disclosed
WO-2023196954-A2 BISPECIFIC BINDING MOLECULES THAT TARGET FSHR AND CD3 THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) 2023-10-12 WO disclosed
WO-2023196953-A2 COMBINATIONS OF BISPECIFIC T CELL ENGAGERS AND METHODS OF USE THEREOF THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) 2023-10-12 WO disclosed
EP-4255484-A1 DESMOGLEIN 2-DIRECTED CHIMERIC ANTIGEN RECEPTOR (CAR) CONSTRUCTS AND METHODS OF USE Thomas Jefferson University (US) 2023-10-11 EP disclosed
WO-2003017363-A1 ADHESIVE TAPE LINTEC CORPORATION (JP) 2003-02-27 WO disclosed
CN-1094958-C Polyacetal resin molded article and process for producing the same ASAHI CHEMICAL IND (JP) 2002-11-27 CN disclosed
WO-2002023273-A2 PHOTOSENSITIVE COMPOSITION, CURED ARTICLE THEREOF, AND PRINTED CIRCUIT BOARD USING THE SAME SHOWA DENKO K.K. (JP) 2002-03-21 WO disclosed
CN-1319109-A Polyoxymethylene copolymer and composition thereof ASAHI CHEMICAL IND (JP) 2001-10-24 CN disclosed
CN-1315972-A Low-molecular oxymethylene polymer and composition thereof ASAHI CHEMICAL IND (JP) 2001-10-03 CN disclosed
CN-1194658-A Polyacetal resin moldings and process for producing the same ASAHI CHEMICAL IND (JP) 1998-09-30 CN disclosed
CN-1106840-A Thermoplastic composition comprising a compatibilized polyphenylene etherpolyamide base resin, one or more phosphorus compounds GEN ELECTRIC (US) 1995-08-16 CN disclosed
JP-S58153785-A SURFACE TREATMENT OF ZINC ELECTROPLATED STEEL PLATE KAWASAKI STEEL CORP 1983-09-12 JP disclosed