Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.78 |
| ▸ | NPC1 | O15118 | 3/20 | 0.78 |
| ▸ | POLB | P06746 | 3/20 | 0.78 |
| ▸ | MEN1 | O00255 | 2/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.75 |
| ▸ | ATM | Q13315 | 1/20 | 0.75 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.64 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29744041 | 1.00 | RAB9A (0.78) | RAB9ANPC1POLBMEN1KMT2A | |
| Indole-2-Carboxylic Acid SCHEMBL14158195 | 0.96 | RAB9A (0.72) | RAB9ANPC1POLBMEN1KMT2A | |
| SCHEMBL14158447 | 0.96 | RAB9A (0.72) | RAB9ANPC1POLBMEN1KMT2A | |
| SCHEMBL12803717 | 0.82 | AKR1C3 (0.67) | POLBAKR1C3HRH4HRH3SMN1; SMN2 | |
| SCHEMBL29465452 | 0.81 | HRH4 (0.68) | POLBMEN1KMT2AAKR1C3HRH4 | |
| SCHEMBL22615235 | 0.81 | HRH4 (0.68) | POLBMEN1KMT2AAKR1C3HRH4 | |
| SCHEMBL13173585 | 0.81 | AKR1C3 (0.57) | RAB9ANPC1POLBMEN1KMT2A | |
| SCHEMBL4362902 | 0.81 | AKR1C3 (0.71) | POLBAKR1C3HRH4HRH3SMN1; SMN2 | |
| SCHEMBL13174681 | 0.81 | AKR1C3 (0.67) | RAB9ANPC1POLBMEN1KMT2A | |
| SCHEMBL15962961 | 0.80 | AKR1C3 (0.80) | POLBAKR1C3HRH4HRH3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846684-B2 | Arbovirus inhibitors and uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-09-30 | — | — | US | disclosed |
| US-8846684-B2 | Arbovirus inhibitors and uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-09-30 | — | — | US | disclosed |
| US-8846684-B2 | Arbovirus inhibitors and uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-09-30 | — | — | US | disclosed |
| WO-2012170098-A2 | ARBOVIRUS INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-12-13 | — | — | WO | disclosed |
| US-20120252807-A1 | ARBOVIRUS INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-10-04 | — | — | US | disclosed |
| US-20120252807-A1 | ARBOVIRUS INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-10-04 | — | — | US | disclosed |
| US-20120252807-A1 | ARBOVIRUS INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252807-A1 | ARBOVIRUS INHIBITORS AND USES THEREOF | ACE, ACE2, MME | RAB9A 2037/4885NPC1 1232/4885POLB 2352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.