SCHEMBL12809271

SCHEMBL12809271

COC(=O)/C=C/c1cc2ccccc2s1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.51
TUBB4A P04350 2/20 0.51
TUBB P07437 2/20 0.51
TUBA3C P0DPH7 2/20 0.51
TUBA1B P68363 2/20 0.51
TUBA4A P68366 2/20 0.51
TUBB4B P68371 2/20 0.51
TUBB3 Q13509 2/20 0.51
TUBB2A Q13885 2/20 0.51
TUBB8 Q3ZCM7 2/20 0.51
TUBA3E Q6PEY2 2/20 0.51
TUBA1A Q71U36 2/20 0.51
TUBA1C Q9BQE3 2/20 0.51
TUBB6 Q9BUF5 2/20 0.51
TUBB2B Q9BVA1 2/20 0.51
TUBB1 Q9H4B7 2/20 0.51
KDM4E B2RXH2 2/20 0.48
KMT2A Q03164 2/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
ALDH1A1 P00352 3/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28874860 1.00 CYP2A6 (0.51) CYP2A6TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL1903000 0.84 CYP2A6 (0.47) CYP2A6TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL6965217 0.84 CYP2A6 (0.47) CYP2A6TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL1903001 0.84 CYP2A6 (0.47) CYP2A6TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL6965215 0.84 CYP2A6 (0.47) CYP2A6TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL10761626 0.83 TUBB4A (0.47) CYP2A6TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL30963015 0.83 CYP2A6 (0.56) CYP2A6TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL29247895 0.83 CYP2A6 (0.56) CYP2A6TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL1226095 0.81 CYP2A6 (0.58) CYP2A6TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL1226099 0.81 CYP2A6 (0.58) CYP2A6TUBB4ATUBBTUBA3CTUBA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1814848-B9 2,3,4-SUBSTITUTED-CYCLOPENTANONES AS THERAPEUTIC AGENTS ALLERGAN INC (US) 2011-12-21 EP disclosed
EP-1814848-B1 2,3,4-SUBSTITUTED-CYCLOPENTANONES AS THERAPEUTIC AGENTS ALLERGAN INC (US) 2010-07-28 EP disclosed
US-7183324-B2 2,3,4-substituted cyclopentanones as therapeutic agents ALLERGAN, INC. (US) 2007-02-27 US disclosed
US-7183324-B2 2,3,4-substituted cyclopentanones as therapeutic agents ALLERGAN, INC. (US) 2007-02-27 US disclosed